重度子痫前期纠正低蛋白血症对预后的影响

目的通过随机对照研究，探讨静脉输注白蛋白纠正重度子痫前期合并低蛋白血症对预后的影响，验证其有效性及安全性。方法126例孕龄32～34周重度子痫前期合并低蛋白血症的孕妇，随机分为治疗组及对照组，分别予积极纠正低蛋白血症治疗及仅维持血清白蛋白20g／L以上治疗，观察两组剖宫产率、胎盘早剥率、产后出血率、子痫率，胎儿窘迫发生率及新生儿窒息发生率等预后及对肝肾功能的影响。结果治疗组剖宫产率、胎盘早剥率、产后出血率、子痫率；胎儿窘迫发生率及新生儿窒息发生率有显著降低；有减少患者急性左心衰发作趋势，肝酶、血清肌酐、尿蛋白未见加重并在产后1周时肝酶较对照组有改善的趋势。结论在重度子痫前期合并低蛋白血症患者中输注人血白蛋白积极纠正低蛋白血症是安全有效的。

The influence in severe preeclampsia patients with hypoalbuminemia on prognosis by corrected hypoalbuminemia

Objective To investigate the influence on prognosis of the Patients with severe preeclampsia with hypoalbuminemia by intravenous human serum albumin to correct hypoalbuminemia,and Verify the Efficacy and safety of the treatment. Methods 126 patients whose gestational age between 32 to 34 weeks with severe preeclampsia with hypoalbuminemia,were randomly divided into treatment group and control group,In experimental group,serum albumin of the patients supplement to no less than 30g/L and in control group,serum albumin only to about 20g/L, calculated cesarean section rate,rate of placental abruption,postpartum hemorrhage rate,the rate of eclampsia,rate of fetal distress,rate of neonatal asphyxia,effects on liver and kidney function of the patients. Results In experimental group cesarean delivery rate,rate of placental abruption,postpartum hemorrhage rate,the rate of eclampsia,rate of fetal distress and neonatal asphyxia rate of the patient had obviously decreased,and has a tendency to reduce patients the incidence of acute left heart failure.Liver function and renal function did not worsen,but liver function had an improving tendency after one week compared with the control group. Conclusion In patients with severe preeclampsia with hypoalbuminemia,Intravenous human serum albumin to correct hypoalbuminemia is safe and effective.