Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia. |
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Authors: | T Ito H Yamadera R Ito H Suzuki K Asayama S Endo |
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Affiliation: | Department of Neuropsychiatry, Nippon Medical School, Tama Nagayama Hospital, Tokyo, Japan. itohtakao/psych@nms.ac.jp |
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Abstract: | The present study investigated the effects of vitamin B12 (VB12) on circadian rhythm in Alzheimer-type dementia (ATD). Twenty-eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB12 with BLT (BLT + VB12). We evaluated the cognitive state with Mini-Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week-BLT caused no significant effects on the circadian rhythm; BLT + VB12 improved the vigilance level during the daytime. These results suggest that VB12 has some efficiency to enhance vigilance for ATD patients. |
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Keywords: | actigraphy Alzheimer‐type dementia bright light therapy circadian rhythm cognitive state vitamin B12 |
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