| 丙泊酚和异氟烷对老年患者术后认知功能障碍的影响 |
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| 引用本文： | 肖军,郑利民,王明玲,余晓利. 丙泊酚和异氟烷对老年患者术后认知功能障碍的影响[J]. 中国现代医生, 2010, 48(11): 80-81 |
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| 作者姓名： | 肖军 郑利民 王明玲 余晓利 |
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| 作者单位： | 1. 北京大学深圳医院麻醉科,广东深圳,518036
2. 湖北汉川市第二人民医院,湖北汉川,432300 |
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| 摘 要： | 目的比较丙泊酚和异氟烷对老年患者术后早期认知功能的影响。方法选择ASAⅠ～Ⅱ级的患者56例行择期上腹部手术，年龄≥65岁，随机分为丙泊酚组和异氟烷组，每组28例。于麻醉前及术后6、12、24和48h采用简易智力状态检查表（MMSE）评价认知功能。结果丙泊酚组患者术后苏醒时间、拔管时间和拔管后语言应答时间均早于异氟烷组（P〈0．05）。结论丙泊酚和异氟烷均可降低老年患者术后早期的认知功能，但丙泊酚较异氟烷苏醒快，认知功能恢复早。
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| 关 键 词： | 丙泊酚 异氟烷 双频脑电指数 认知功能障碍 |
Effects of Disoprofol and Isoflurane on Postoperative Cognitive Dysfunction in the Elderly |
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| XIAO Jun,HENG Limin,ANG Mingling,YU Xiaoli. Effects of Disoprofol and Isoflurane on Postoperative Cognitive Dysfunction in the Elderly[J]. , 2010, 48(11): 80-81 |
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| Authors: | XIAO Jun HENG Limin ANG Mingling YU Xiaoli |
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| Affiliation: | 1.Department of Anesthesiology, Shenzhen Hospital of Peking University, Shenzhen 518036, China; 2.The Second People＇s Hospital in Hubei, Hanchuan 432300, China) |
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| Abstract: | Objective To investigate the effects of disoprofol and isoflurane on the postoperative cognitive dysfunction in the elderly. Methods Fifty-six cases of ASA Ⅰ-Ⅱ（age ≥ 65 years）to undergo upper abdominal surgery were randomly assigned to disoprofol group（n=28 ）and isoflurane group（n=28 ）. The mini-mental state examination（MMSE ） was used to assess the cognitive function before and at 6,12,24 and 48h after operation. Results Postoperative recovery time,extubation time and language response time after extubation were markedly shorter in the disoprofol group than those of the isoflurane group（P〈0.05 ）. Conclusion Both disoprofol and isoflurane can decline postoperative early cognitive function in the elderly, but the former shows earlier awakening and faster recovery of cognitive function than the latter. |
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| Keywords: | Disoprofol Isoflurane Bispectral index Postoperative cognitive dysfunction |
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