Effect of the hypothalamic cardioactive protein-hormonal complex on choline sensitivity of the small intestine and contraction of the vas deferens in rats

A cardioactive protein-hormonal complex capable of increasing the sensitivity of the small intestine to acetylcholine about 2.5 times was isolated from magnocellular nuclei of the hypothalamo-neurohypophyseal system. Moreover, this complex enhanced contraction of the vas deferens caused by transmural stimulation, exogenous noradrenalin, and phenylephrine. The findings indicate release of transmitters from cholinergic and adrenergic neurons under the influence of the complex. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 3, pp. 280–282, March, 1995