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Organ pattern of age-related changes in the aminoacyl-tRNA synthetase activities of the mouse |
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| Authors: | Hans-Joachim Gabius Sigrun Goldbach Gerhart Graupner Sabine Rehm Friedrich Cramer |
| Institution: | a Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Strasse 3, D-3400, Göttingen, F.R.G. b Zentralinstitut für Versuchstiere, Lettow- Vorbeck-Allee 57, D-3000, Hannover 91, F.R.G. |
| Abstract: | The specific activities of 17 aminoacyl-tRNA synthetases from liver, lung, heart, spleen, kidney, small intestine and skeletal muscle of young (2 months) and aged (39 months) female Han:NMRI mice were determined under standard conditions of sample preparation and assay. The average reduction of total activity during ageing is 70% for liver, 50% for lung and spleen, nearly 40% for heart and kidney and nearly 20% for intestine and skeletal muscle. Detailed comparison reveals no general, but an organ-specific pattern. Aminoacyl-tRNA synthetases were, furthermore, found to be ribosome-associated in higher proportions in liver tissue from aged mice. |
| Keywords: | To whom correspondence should be addressed |
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