| Allogeneic Peripheral Blood Hematopoietic Stem Cell Transplantation for Patients with Hematologic Malignancies |
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| 作者姓名： | 夏凌辉 方峻 游泳 郭涛 刘芳 张纯 江汇娟 邹萍 |
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| 作者单位： | Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China，Institute of Hematology Union Hospital TongjiMedical College Huazhong University of Science and Technology Wuhan 430022 China |
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| 摘 要： | Allogeneic peripheral blood stem cell trans-plantation(allo-PBSCT)is one of the most effec-tive approaches for malignant hematopoietic disea-ses.Advantages of allo-PBSCT over allogeneicbone marrowtransplantation(allo-BMT)include aquicker hematopoietic reconstructionfor the recipi-ent andfewer complications of infection.To evalu-ate the therapeutic effects and associated complica-tions of allo-PBSCT,weinvestigated40cases trea-ted with allo-PBSCTfromJune2000to May2005in our hospital.1M…
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| 关 键 词： | 外周血 造血干细胞 细胞移植 血液疾病 |
| 收稿时间： | 2005-05-08 |
Allogeneic peripheral blood hematopoietic stem cell transplantation for patients with hematologic malignancies |
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| Xia Linghui,Fang Jun,You Yong,Guo Tao,Liu Fang,Zhang Chun,Jiang Huijuan,Zou Ping.Allogeneic Peripheral Blood Hematopoietic Stem Cell Transplantation for Patients with Hematologic Malignancies[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(1):47-49. |
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| Authors: | Xia Linghui Fang Jun You Yong Guo Tao Liu Fang Zhang Chun Jiang Huijuan Zou Ping |
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| Institution: | Institute of Hematology, Union Hospital, TongjiMedical College, Huazhong University of Science and Technology,Wuhan 430022, China |
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| Abstract: | Summary To investigate the therapeutic effects and associated complications of allogeneic peripheral blood stem cell transplantation
(allo-PBSCT). 10 patients with various malignant hematopoietic diseases received allo PBSCT. The preparative regimens were
based on BUCY2 or modified BUCY2. The acute graft versus host disease (aGVIII) was prevented by cyclosporin A and shortterm
MTX regimen in all patients. Two patients from donors with one fully mismatched HLA on DRB1 locus and 4 from unrelated donor
also administered Zenapox (CD25 MAb) at dosage of 1 mg/kg every day on the day before transplantation and day 1 after transplantation.
These 6 patients were also treated with mycophenolate mofetil (MMF). Transfusion of the donor cells: The median of the transfused
nucleated cells was 5.38<108/kg and that of the CD34′ cells was 7.8×106/kg respectively. All the patients gained hematopoietic reconstruction except one who died of infection before engraftment.
Seven patients got II′ IVo aGVHD, and the incidence was 17.5%. Fourteen patients got cGVHD and the incidence was 53.8% in the patients who survived
over 6 months. Twenty-eight patients had fever or other characteristics of infection. The median follow-up time was 13.8 months.
The incidence of transplantation related mortality (TRM) was 17.5% and 2 patients relapsed (5.0_). It was concluded that allo
PBSCT can reconstruct hematopoiesis quickly and is a favorable therapeutic method for leukemia.
XIA Linghui, male, born in 1964. Associate Professor |
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| Keywords: | leukemia peripheral blood stem cell transplantation allogeneic graft-vesus-host disease |
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