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| 咖啡酸、阿魏酸和香草酸对酪氨酸酶活性的影响 | |
| 引用本文： | 闫军,李昌生,陈声利,张君仁. 咖啡酸、阿魏酸和香草酸对酪氨酸酶活性的影响[J]. 中国临床药理学与治疗学, 2004, 9(3): 337-339 |
| 作者姓名： | 闫军 李昌生 陈声利 张君仁 |
| 作者单位： | 1. 济南市皮肤病防治院药剂科,济南,250001,山东 2. 山东省皮肤病性病研究所皮肤科,济南,250022,山东 3. 山东大学药学院药物分析教研室,济南,250012,山东 |
| 摘 要： | 目的 :研究咖啡酸、阿魏酸和香草酸对酪氨酸酶活性的影响 ,寻找酪氨酸酶抑制剂 ,从而为治疗色素增加性皮肤病筛选药物。方法 :酪氨酸酶多巴速率氧化法体外测定药物干预前后酪氨酸酶活性 ,求出酪氨酸酶抑制率。采用Lineweaver Burk双倒数法制得酶动力学曲线 ,推断抑制类型。结果 :3种试药中仅香草酸对酪氨酸酶具有抑制作用 ,与氢醌比较无显著差异 (P >0 .0 5 ) ,咖啡酸、阿魏酸对酪氨酸酶具有上调激活作用。结论 :香草酸为良好的混合型酪氨酸酶抑制剂。 |
| 关 键 词： | 咖啡酸 阿魏酸 香草酸 酪氨酸酶 抑制剂 |
| 文章编号： | 1009-2501(2004)03-0337-03 |
| 修稿时间： | 2003-10-13 |
Effects of caffeic acid, ferulic acid and vanillic acid on tyrosinase |
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| YAN Jun,LI Chang Sheng,CHEN Sheng Li ,ZHANG Jun Ren. Effects of caffeic acid, ferulic acid and vanillic acid on tyrosinase[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 337-339 | |
| Authors: | YAN Jun LI Chang Sheng CHEN Sheng Li ZHANG Jun Ren |
| Affiliation: | YAN Jun,LI Chang Sheng,CHEN Sheng Li 1,ZHANG Jun Ren 2 Department of Pharmacy,Jinan Hospital for Skin Diseases Prevention,Jinan 250001,Shandong,China, 1 Department of Dermatology,Shandong Provincial Institute of Dermatology and Venereology,Jinan 250022,Shandong,China, 2 Department of Pharmaceutical Analysis,School of Pharmacy,Shandong University,Jinan 250012,Shandong,China |
| Abstract: | AIM: To evaluate the effects of monomers of caffeic acid, ferulic acid and vanillic acid on the activity of tyrosinase, so as to provide a kind of drug in the treatment of hyperpigmentation. METHODS: Tyrosinase activity was estimated by measuring the oxidation rate of L DOPA. The inhibitory pattern of each monomer was determined according to their Lineweaver Burk curve compared to the controlled group. RESULTS: Vanillic acid showed an inhibition to tyrosinase activity, and the rate of inhibitory was similar to hydroquinone, which had no statistically significant difference between them (P> 0.05 ). Caffeic acid and ferulic acid showed an up regulation to tyrosinase activity. CONCLUSION: Vanillic acid, a mixed type inhibitor of tyrosinase, can inhibit the activity of tyrosinase greatly. |
| Keywords: | caffeic acid ferulic acid vanillic acid tyrosinase inhibitor |
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