| INDUCTION OF APOPTOSIS BY SeO_2 IN HUMAN LUNG CARCINOMA CELL LINE GLC-82 |
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| 作者姓名： | 陈维香 曹晓哲 朱任之 刘炜 |
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| 作者单位： | Department of Pathology，Gongli Hospital of Pudong New Area，Department of Pathology，Lanzhou General Hospital of PLA，Department of Pathology，Lanzhou Medical College，Department of Pathology，Lanzhou General Hospital of PLA Shanghai 200135，Lanzhou 730050，Lanzhou 730000，Lanzhou 730050 |
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| 基金项目： | Thisworkwassupportedbyagrantfrom9thfive-yearplanyouthprojectofPLA(No.98Q010). |
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| 摘 要： | Thetraceelementselenium(Se)hasbeenshowntobecytotoxicinvitroinmultiplecellmodelsincludingbreastcancercelllineMCF-71],coloniccarcinomacellsHT292]andimmortalhumanhepaticcelllineHL-77023].Seleniumisanessentialcomponentofanumberofenzymespresentintheaminoacidselenocysteine(Se-Cys)andinhibittumorigenesisinbothanimalmodelsandhumans3].SupplementingwithSeindietmayreducethehumancancerrisk3].Clarketal.4]foundthattheincidentoflungcancerwaslowerinSe-supplementedpatients.Apoptosisinducedbyselenium…
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INDUCTION OF APOPTOSIS BY SeO2 IN HUMAN LUNG CARCINOMA CELL LINE GLC-82 |
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| CHEN Wei-xiang ,CAO Xiao-zhe ,ZHU Ren-zhi ,LIU Wei.INDUCTION OF APOPTOSIS BY SeO_2 IN HUMAN LUNG CARCINOMA CELL LINE GLC-82[J].Chinese Journal of Cancer Research,2004,16(3). |
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| Authors: | CHEN Wei-xiang CAO Xiao-zhe ZHU Ren-zhi LIU Wei |
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| Institution: | CHEN Wei-xiang 2,CAO Xiao-zhe 1*,ZHU Ren-zhi 3,LIU Wei 1 1Department of Pathology,Lanzhou General Hospital of PLA,Lanzhou 730050 2Department of Pathology,Gongli Hospital of Pudong New Area,Shanghai 200135 3Department of Pathology,Lanzhou Medical College,Lanzhou 730000 |
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| Abstract: | Objective: To investigate the effect of selenium dioxide (SeO2) on human pulmonary adenocarcinoma GLC-82 cell lines to reveal its probable mechanism and the relationship between apoptosis and SeO2. Methods: Methyl thiazolyl tetrazolium (MTT) method, flow cytometry (FCM), DNA agarose gel electrophoresis, light and electron microscope were used to study cell apoptosis in human pulmonary adenocarcinoma cell line GLC-82 treated by SeO2 at different concentrations (3, 10, 30 mmol/L) and for different times (24, 48, and 72 h). Results: SeO2 significantly inhibited the proliferation and induced the cell apoptosis of GLC-82 at the different concentrations after treatment of 48 h and 72 h. Conclusion: Selenium dioxide could inhibit the growth of lung cancer GLC-82 cells through inducing apoptosis. The effect of inhibition is dose-dependant and time-dependant. |
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| Keywords: | SeO_2 Proliferation Apoptosis GLC-82 |
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