| 藻酸双酯钠对实验性心肌梗塞动物缺血性损伤的保护作用 |
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| 引用本文： | 刘赛 王春波. 藻酸双酯钠对实验性心肌梗塞动物缺血性损伤的保护作用[J]. 中国药理学通报, 1993, 9(3): 207-209 |
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| 作者姓名： | 刘赛 王春波 |
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| 作者单位： | 青岛医学院药理教研室 山东266012(刘赛，王春波，郭沈波，于维森)，青岛医学院附属医院护校 山东266012(于桂英)，青岛医学院药理教研室 山东266012(闫应举) |
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| 摘 要： | 本文采用两种实验性心肌梗塞动物模型.观察藻酸双酯钠(PSS)抗心肌缺血的作用。实验结果显示,PSS能降低高位结扎冠状动脉前降支后引起的家兔心电四ST段异常抬高的程度(∑ST)以及病理性Q波出现数(NQ),缩小家兔心肌梗塞范围(MIS).并使血清CPK活性降低;PSS亦能减轻异丙肾上腺素引起的大鼠心电图上缺血性损伤变化.降低心肌CPK活性,提示PSS对心肌缺血性损伤具有保护作用.
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| 关 键 词： | 藻酸双酯钠 实验性心肌梗塞 异丙肾上腺素 |
Pharmacological studies on poly-saccharide sulphate: protective effects on experimental myocardial infarction in rabbits and myocardial necrosis induced by isoprenaline in rats |
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| LIU Sai,WANG Chun-Bo,GUO Shen-Bo. Pharmacological studies on poly-saccharide sulphate: protective effects on experimental myocardial infarction in rabbits and myocardial necrosis induced by isoprenaline in rats[J]. Chinese Pharmacological Bulletin, 1993, 9(3): 207-209 |
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| Authors: | LIU Sai WANG Chun-Bo GUO Shen-Bo |
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| Abstract: | This study reported the protective effects of poly-saccharide sulphate (PSS) on experimental model of myocardial infaction by high positioned double - ligation of the anterior descending left coronary artery in rabbits, and on ischemic injury of myocardium by intraperi-toneal injection of isoprenaline in rats. The results showed that PSS could decrease the infarct sizes of rabbits model expressed by ECG mappingof ∑ST segment, NST and NQ, and reduce the activities of CPK in serum. It also showed that PSS reduced the severity of myocardial necrosis and the activies of CPK in serum of the experimental rats . It suggested that PSS have the protective effects on ischemic injury of myocardium. |
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| Keywords: | PSS isoprenaline myocardial infarction |
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