复方扶芳藤合剂对心力衰竭患者神经内分泌因子及心功能的影响

目的探讨复方扶芳藤合剂对心力衰竭患者神经内分泌因子及心功能的影响。方法选择2012年1～9月住院治疗的心力衰竭患者64例,按数字表法随机分为两组,对照组32例,给予常规治疗;治疗组32例,在对照组治疗的基础上每天口服2次复方扶芳藤舍剂,每次15mL。比较两组治疗后的血管紧张素Ⅱ、超敏C-反应蛋白（hs—CRP）、B型脑钠素（BNP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNpa）的水平。结果两组治疗前各指标差异无统计学意义（P〉0．05）;治疗后,治疗组及对照组各指标均有下降,与治疗前比较差异有统计学意义（P〈0．01）;治疗组治疗后各指标下降较对照组更明显,差异有统计学意义（P〈0．05）。两组治疗后心功能均有改善,治疗组治疗后心功能分级明显优于对照组,差异有统计学意义（P〈0．05）。结论复方扶芳藤合剂对心力衰竭患者的神经内分泌功能有一定的调节作用,可改善患者心功能,值得临床推广应用。

Study on influence of Compound Fufangteng Mixture on neuroendocrine factors and cardiac function in patients with heart failure

Objective To investigate the impact of Compound Fufangteng Mixture on the neuroendocrine fac- tors and the cardiac function in the patients with heart failurel Methods 64 inpatients with heart failure in our hospi- tal from January to September 2012 were selected and randomly divided into the treatment and the control groups ac- cording to the random number table. The control group（ 32 cases） underwent the conventional therapy, while on the basis of the control group treatment, the treatment group was given Compound Fufangteng Mixture, twice daily, 15mL each time. Then the levels of angiotensin II , hs-CRP, BNP, IL-6 and TNF-α were detected and compared be- tween the two group after treatment. Results All the indicators before treatment in the two groups had no obvious differences（P〉0.05）. The various indexes after treatment in the two groups were decreased with statistical differ- ences compared with before treatment（P〈0. 01）;the decrease of various indexes after treatment in the treatment group was more obvious than the control group（P〈0.05）. The cardiac function was affectively improved in the two group after treatment,but the grades of cardiac function in the treatment group were superior to those in the control group,with statistical difference（P〈0.05）. Conclusion Compound Fufangteng Mixture has some regulating effect on the neuroendocrine function of the patients with heart failure,and improves the cardiac function of patients, which is worth to be promoted and applied in clinic.