| 肝癌及癌旁肝组织中caveolin 1表达及其意义 |
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| 引用本文： | 赵伊遐,付蕾,席蕾,冯德云.肝癌及癌旁肝组织中caveolin 1表达及其意义[J].中国普通外科杂志,2007,16(9):11-871. |
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| 作者姓名： | 赵伊遐 付蕾 席蕾 冯德云 |
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| 作者单位： | 1. 中南大学湘雅医学院2003级临床学专业,湖南,长沙,410078
2. 中南大学湘雅医学院病理学系,湖南,长沙,410078 |
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| 基金项目： | 中南大学大学生创新教育资助项目 |
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| 摘 要： | 摘要：目的探讨肝癌及癌旁肝组织中caveolin 1蛋白和mRNA的表达及其意义。方法利用免疫组化和原位杂交技术检测10例正常肝组织和50例肝癌及其癌旁肝组织中caveolin 1蛋白和mRNA的表达，并分析其与肝癌生物学行为的关系。结果肝细胞癌（HCC）中caveolin 1蛋白和mRNA表达的细胞主要为血管内皮细胞，其表达强度与HCC的分化程度无关。癌旁肝组织中caveolin 1蛋白和mRNA阳性信号多位于肝窦内皮细胞、肝星状细胞、血管内皮细胞和增生的胆管上皮细胞。caveolin 1蛋白和mRNA在肝硬化及不典型增生的癌旁组织的肝细胞中呈强表达。在胆管细胞性肝癌组织中，癌细胞和血管内皮细胞均呈强阳性。caveolin 1蛋白和mRNA在胆管细胞性肝癌中表达强度显著高于HCC；HBsAg和AFP阳性的肝癌患者的表达强度明显低于阴性患者。结论 HCC中caveolin 1蛋白和mRNA低表达或表达缺失可能是HCC较胆管细胞性肝癌恶性程度高、生长快和易发生转移的重要原因；检测caveolin 1表达有可能作为鉴别HCC和胆管细胞性肝癌的有用指标之一。
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| 关 键 词： | 肝肿瘤/病理学 |
| 文章编号： | 1005-6947（2007）09-0867-05 |
| 收稿时间： | 2007-08-17 |
| 修稿时间： | 2007-08-27 |
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| ZHAO Yi xia,FU Lei,XI Lei,FENG De yun.[J].Chinese Journal of General Surgery,2007,16(9):11-871. |
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| Authors: | ZHAO Yi xia FU Lei XI Lei FENG De yun |
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| Institution: | 1. Student of 2003 class 2. Department of Pathology, Xiangya School of Medicine, Changsha 410078, China |
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| Abstract: | Objective To study the expression and significance of caveolin-1 protein and mRNA in liver cancers and paracancer liver tissues.Methods The expressions of caveolin-1 protein and mRNA were detected by immunohistochemistry and in situ hybridization in 10 cases of normal liver tissue,and 50 cases of liver cancer and paracancer liver tissue.Results Caveolin-1 protein and mRNA were mainly expressed in vascular endothelial cells in hepatocellular carcinomas(HCC).The expression intensities of caveolin-1 protein and mRNA were not related to differentiation degree of HCCs.In paracancer liver tissues,the positive signal of caveolin-1 protein and mRNA was localized at sinusoidal endothelial cells,hepatic stellate cells,vascular endothelial cells and proliferative bile duct epithelial cells The hepatocytes in liver cirrhosis and paracancer tissues with atypical hyperplasia over-expressed caveolin-1 protein and mRNA.Cancer cells and vascular endothelial cells in cholangiocellular carcinomas all over-expressed caveolin-1 protein and mRNA.The expression intensities of caveolin-1 protein and mRNA in cholangiocellular carcinomas were significantly higher than those in HCCs.The expression intensities of caveolin-1 protein and mRNA in patients with HBsAg and AFP positive HCC were obviously lower than those in patients with HBsAg and AFP negative HCC.Conclusions The weak or deleted expression of caveolin-1 protein and mRNA in HCCs may be an important reason for the high degree of malignancy,rapid growth rate and frequent occurrence of metastasis in contrast to cholangiocellular carcinoma.Detection of caveolin-1 expression may be one of the useful indexes for differentiation of HCC from cholangiocellular carcinoma. |
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| Keywords: | caveolin-1 |
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