|
|||||
|
|
| 河南食管癌高发区食管贲门双源癌粘蛋白1、C-erbB2蛋白的表达 | |
| 引用本文： | 陈虹,王立东,高社干,范宗民,郭花芹,李吉林,郭梅. 河南食管癌高发区食管贲门双源癌粘蛋白1、C-erbB2蛋白的表达[J]. 郑州大学学报(医学版), 2002, 37(6): 758-761 |
| 作者姓名： | 陈虹 王立东 高社干 范宗民 郭花芹 李吉林 郭梅 |
| 作者单位： | 1. 郑州大学医学院癌症研究室,郑州,450052 2. 林州市姚村食管癌医院病理科,林州,456592 3. 安阳市肿瘤医院病理科,安阳,455000 |
| 基金项目： | 国家杰出青年科学基金 3 0 0 2 5 0 16,河南省高校创新人才工程基金,河南省医药卫生创新人才工程基金资助项目 |
| 摘 要： | 目的：探讨同一个体食管贲门双源癌组织粘蛋白1（MUC1）和C－erbB2蛋白变化的特征及其意义。方法：采用免疫组化卵白素－生物素－过氧化物酶复合物（ABC）法和组织病理学方法,分析河南食管癌高发区25例双源癌患者（同时发生食管鳞癌和贲门腺癌）MUC1和C－erbB2蛋白的表达状况。结果：25例患者食管鳞癌和贲门腺癌组织均出现不同程度的MUC1和C－erbB2蛋白的阳性表达。食管癌：MUC1,C-erbB2免疫阳性率分别为80％（20／25）,20％（5／25）;贲门癌：分别为72％（18／25）,48％（12／25）,且免疫反应类型均主要为弥漫型。MUC1,C－erbB2蛋白在食管和贲门双源癌肿瘤组织中具有很高的一致性改变,一致性改变率分别为92％、64％。结论：食管和贲门双源癌存在较高的MUC1和C-erbB2蛋白一致性改变,提示河南食管癌高发区食管贲门双源癌可能具有相似的发病因素和分子机制。 |
| 关 键 词： | 河南 食管癌 高发区 食管贲门 双源癌 粘蛋白1 C－erbB2蛋白 食管鳞癌 贲门腺癌 |
| 修稿时间： | 2002-06-10 |
Alterations of MUC1 and C-erbB2 in concurrent cancers of the esophagus and gastric cardia from the same patient in Linzhou, Henan Province |
|
| CHEN Hong ),WANG Lidong ),GAO Shegan ),FAN Zongmin ),GUO Huaqin ),LI Jilin ),GUO Mei ) )Laboratory for Cancer Research,College of Medicine,Zhengzhou University,Zhengzhou )Yaocun Esophageal Cancer Hospital,Linzhou ). Alterations of MUC1 and C-erbB2 in concurrent cancers of the esophagus and gastric cardia from the same patient in Linzhou, Henan Province[J]. Journal of Zhengzhou University: Med Sci, 2002, 37(6): 758-761 | |
| Authors: | CHEN Hong ) WANG Lidong ) GAO Shegan ) FAN Zongmin ) GUO Huaqin ) LI Jilin ) GUO Mei ) )Laboratory for Cancer Research College of Medicine Zhengzhou University Zhengzhou )Yaocun Esophageal Cancer Hospital Linzhou ) |
| Affiliation: | CHEN Hong 1),WANG Lidong 1),GAO Shegan 1),FAN Zongmin 1),GUO Huaqin 1),LI Jilin 2),GUO Mei 3) 1)Laboratory for Cancer Research,College of Medicine,Zhengzhou University,Zhengzhou 450052 2)Yaocun Esophageal Cancer Hospital,Linzhou 456592 3)Department of Pathology,Anyang Tumor Hospital,Anyang 455000 |
| Abstract: | Aim: To characterize the alteration of MUC1 and C erbB2 in concurrent carcinomas of the esophagus and gastric cardia from the same patient. Method: MUC1 and C erbB2 protein expression in 25 patients with concurrent cancers from esophagus and gastric cardia (CC) in the same patient (occurring together with esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA)) was detected by immunohistochemical method (ABC). Results: In CC patients, both SCC and GCA tissues showed a different extent of MUC 1 and C erbB2 protein positive immunostaining. In SCC, the immunostaining rates of MUC 1 and C erbB2 were 80%(20/25)and 20%(5/25),respectively; in GCA, 72%(18/25)and 48%(12/25), respectively. "Diffuse" immunostaining pattern was frequently observed in MUC1 and C erbB2. The high coincidence of positive staining rates for MUC1 and C erbB2 was observed in SCC and GCA from the same patients, and accounted for 92% and 64%, respectively.Conclusion: The high coincident alterations for MUC1 and C erbB2 in SCC and GCA from the same patient indicate the possibility of similar molecular basis, and similar risk factors for SCC and GCA. |
| Keywords: | concurrent cancer esophageal squamous cell carcinoma gastric cardia adenocarcinoma MUC1 C erbB2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |