心踝血管指数在老年人大动脉硬化诊断中的意义

目的探讨一个新的判断大动脉硬化的指标一心踝血管指数（CAVI）在老年人巾的临床意义。方法用VS-1000动脉硬化检测系统测定了126例老年人的CAVI，同时测定踝肱指数（ABI），颈动脉内膜中层厚度（IMT）和相应的生化指标：结果126例老年人平均年龄81．6±4．8岁，男92例，女34例。CAVI为10．70±4．32，以CAVI≥9定义为异常，异常率为88．1％，与以IMT≥0．9mm定义的大动脉硬化检出率89．7％相似（P〉0．05）。ABI≤0．9即存在外周血管病变（PAD），合并PAD组CAVI为12．0±19．44，无PAD组CAVI为10．38±1．19，两组间有显著性差别（P〈0．01），CAVI与ABI的相关系数为-0．247（P〈0．05）。在这组以高龄老人为主的人群中，在高血压与非高血压组，糖尿病与非糖尿病组以及吸烟与非吸娴组之问，CAVI无显著性差异，CAVI与年龄无相关性（P〉0．05）。结论CAVI可以作为一个无创的大动脉硬化的早期筛查指标之一：但在老年人特别是高龄老人的实际运用中，需联合检测多个无创指标，以便在临床上进行综合分析和判断。

Significance of cardio-ankle vascular index in diagnosis of senile aorta atherosclerosis

Objective To investigate the clinical significance of a new indicator for diagnosing aorta atherosclerosis：cardio-ankle vascular index （CAVI） in old patients. Methods CAVI was detected by applying VS-1000 Atherosclerosis Detective System in 126 old patients （male 92 and female 34）. The anklebrachial index （ABI）,carotid intima-media thichness （IMT） and relevant indexes of biochemistry were determined at the same time. Results The average age of 126 old patients was 81.6 ± 4.8 and their average CAVI was 10.70 ±4.32. The abnormal rate of CAVI was 88.1% （CAVI≥9 defined as abnormal） , which was similar to the detectable rate of senile aorta atherosclerosis （89.7% ,when IMT≥9 mm）. In the group of aorta atherosclerosis accompanied by peripheral artery disease （PAD） CAVI was 12.0 ± 19.44 and that was 10.38 ± 1.19 in the group without PAD. There was a significant difference between two groups （P 〈 0.01 ）. The correlative coefficient between CAVI and ABI was -0. 247 （ P 〈 0.05 ）. There was no significam difference in CAVI between hypertension group and non-hypertension group,diabetes group and non-diabetes group,or smoking group and non- smoking group respectively. CAVI was no con＇elated to age （P 〉 0.05 ）. Conclusion CAVI can be taken as one of indicators for screening aorta atherosclerosis non-invasively,while which should be combined with nmhiple noninvasive indicators used in senile patients in order to clinical comprehensive analysis and diagnosis.