Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain |
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| Authors: | P C Contreras R Quirion D R Gehlert M L Contreras T L O'Donohue |
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| Affiliation: | 1. Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Department of Pharmacology and Toxicology, Faculty of medicine, University of Toronto, Toronto, Canada;1. Institute of Behavioral and Physical Sciences, College of Life Sciences, Northwest Normal University, Lanzhou, 730070, Gansu, China;2. Institute of Pharmacology, School of Pharmacology, Lanzhou University, 73000 Lanzhou, Gansu, China |
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| Abstract: | The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pallidus, substantia nigra, and inferior and superior colliculi. In contrast, the distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, were much more extensive. Some areas containing the highest density of sites labeled by [3H]haloperidol were the external plexiform layer of the olfactory bulb, the cerebral cortex, the paraventricular nuclei, the interpeduncular nucleus and the superior colliculus. The distribution of non-dopaminergic binding sites labeled by haloperidol was clearly quite different from that labeled by dopaminergic ligands. |
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