| 5羟色胺1A(5-HT_(1A))受体参与调制大鼠丘脑中央下核5-HT诱发的抗伤害感受效应 |
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| 引用本文： | 肖丹秦,朱娟霞,贾红,唐敬师. 5羟色胺1A(5-HT_(1A))受体参与调制大鼠丘脑中央下核5-HT诱发的抗伤害感受效应[J]. 陕西医学杂志, 2006, 35(9): 1073-1076 |
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| 作者姓名： | 肖丹秦 朱娟霞 贾红 唐敬师 |
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| 作者单位： | 1. 西安医学院生理教研室,西安,710068
2. 西安交通大学医学院生理教研室 |
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| 摘 要： | 目的:研究5-HT1A受体是否参与调节中虫下核(Sm)内由5-HT引起的抗伤害效应。方法:以辐射热诱发浅麻大鼠甩尾(TF)反射潜伏期为痛反应指标,在Sm内单独微量注射5-HT1A受体拮抗剂。结果:5-HT1A受体拮抗剂p-MPPI(0.87nmol)可易化TF反射,小剂量的p-MPPI(0.43nmol)可明显减弱Sm内注射5-HT后引起的甩尾(TF)反射抑制效应。结论:5-HT1A受体参与调制大鼠丘脑中央下核5-HT诱发的抗伤害感受效应。
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| 关 键 词： | 丘脑后核/病理生理学 丘脑后核/药物作用 受体,血清素 血清素/治疗应用 大鼠 |
| 收稿时间： | 2006-05-15 |
| 修稿时间： | 2006-05-15 |
5 Hydroxytryptamine 1A (5-HT1A) receptor is involved in mediating he nucleus submedius 5HT-evoked antinociception in rats |
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| Xiao Danqin ,Zhu Juanxia, Jia Hong ,el al. 5 Hydroxytryptamine 1A (5-HT1A) receptor is involved in mediating he nucleus submedius 5HT-evoked antinociception in rats[J]. Shaanxi Medical Journal, 2006, 35(9): 1073-1076 |
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| Authors: | Xiao Danqin Zhu Juanxia Jia Hong el al |
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| Affiliation: | Xi'an 710068 |
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| Abstract: | Objective: To examine whether the 5-HT_ 1A receptors are involved in the Sm 5-HT-evoked antinociception. Methods: Nociception was assessed in lightly anesthetized rats with radiant -heat- evoked tail flick (TF). 5-HT_ 1A receptor antagonist was microinjected into the Sm alone or in combination with a microinjection of 5-HT into the same Sm site. Results: 5-HT_ 1A receptor antagonist p-MPPI (0.87 nmol) facilitated the TF reflex; a lower dose (0.43 nmol) of p-MPPI significantly attenuated the Sm 5-HT- evoked inhibition of TF reflex. Conclusion: 5-HT_ 1A receptor is involved in mediating the 5-HT-evoked antinociception. |
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| Keywords: | Posterior thalamic nuclei /physiopathology Posterior thalamic nuclei / drug effects Receptors serotonin Serotonin/therapeutic use Rats |
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