| 子宫内膜癌组织中内皮抑素的表达及与血管形成的关系 |
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| 引用本文： | 黄双英,张白凌,黄素真,徐惠贞.子宫内膜癌组织中内皮抑素的表达及与血管形成的关系[J].中国误诊学杂志,2009,9(31):7563-7564. |
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| 作者姓名： | 黄双英 张白凌 黄素真 徐惠贞 |
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| 作者单位： | 1. 福建医科大学附属第二医院妇产科,362000
2. 福建医科大学附属口腔医学院病理教研室,350002 |
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| 摘 要： | 目的:探讨内皮抑素(Endostatin)在子宫内膜样腺癌组织中的表达及其与肿瘤血管形成的关系.方法:应用免疫组织化学方法(MaxVision法)检测66例子宫内膜样腺癌组织及26例增生期子宫内膜组织中内皮抑素的表达及CD34标记的MVD.结果:内皮抑素和MVD在子宫内膜样腺癌组织中高表达(P<0.01),与子宫内膜样腺癌分期有关(P<0.05).结论:内皮抑素检测可作为评价子宫内膜样腺癌生物学参数的参考指标之一.
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| 关 键 词： | 子宫内膜肿瘤/代谢 内皮抑素类/代谢 新生血管化.病理性 女(雌)性 |
Expression of Endostatin in Endometrioid Adenocarcinoma and Their Relationship to Angiogenesis |
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| Institution: | HUANG Shuang-ying,ZHANG Bai-ling,HUANG Su-zhen,et al. (Department of Gynaecology and Obstetrics ,The Second Hospital Affiliated to Fujian Medical University,Fuzhou 362000,China) |
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| Abstract: | Objective：To investigate the expression of Endostatin in endometrioid adenocarcinoma and their rehtionship to angiogenesis. Methods：The expression of Endostatin in the paraffin-embeded section of 66 cases of en dometrioid adenocarcinoma and 26 cases of proliferative cndometrium was evaluated by immunohistochemistry Max Vi sion technique. MVD of endometrioid adenocarcinoma and proliferative endometrium was also determined with anti CD34 as the label. Results ：The positive rate of Endostatin and MVD in endometrioid adenocarcinoma was higher than in proliferative endometrium. The level of expression of Endostatin in stage≥1 endometrioid adenocarcinoma was higher than in stage I（P〈0.05）. Conclusion ：To deterrnine Endostatin protein in endometrioid adenocareinoma is a reference parameter for evaluation the degree of malignant. |
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| Keywords: | Endometrial Neoplasms/metabolism Endostatins/metabolism Neovascularization Pathologic Female |
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