Delivering silence: advancements in developing siRNA therapeutics |
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| Authors: | Novobrantseva Tatiana I Akinc Akin Borodovsky Anna de Fougerolles Antonin |
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| Institution: | Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, MA 02142, USA. tnovobrantseva@alnylam.com |
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| Abstract: | The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics and gives an overview of the key in vivo delivery technologies in use today. A section is also devoted to currently ongoing clinical trials employing siRNA drugs. |
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