Estimation of Aqueous Solubility for Some Guanine Derivatives Using Partition Coefficient and Melting Temperature |
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| Affiliation: | 1. Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan;2. Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu 300, Taiwan;1. Department of Technology & Home Economics Education, Kongju National University, Kongju 314-701, Republic of Korea;2. Department of Environmental Science, Kongju National University, Kongju 314-701, Republic of Korea;3. Department of Environmental Education, Kongju National University, Kongju 314-701, Republic of Korea;1. Department of Pharmaceutical Analysis, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;2. Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;1. Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA, 24061, United States;2. Department of Chemistry, Virginia Tech, Blacksburg, VA, 24061, United States;3. Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA, 24061, United States;4. Department of Industrial and Physical Pharmacy, College of Pharmacy, West Lafayette, IN, 47907, United States |
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| Abstract: | Aqueous solubilities for some guanine derivatives were estimated by semiempirical equations developed by Yalkowsky and Valvani1 using the data for partition coefficient and melting temperature. It was shown that in the case of guanine derivatives examined in this study, the solubility values could not be estimated adequately by these equations. |
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