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Is the effect of somatostatin on muscarinic receptors selective to M1 type? |
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| Authors: | Rie Miyoshi Shozo Kito Kumiko Mizuno Hiroaki Matsubayashi |
| Institution: | 1. Cognitive Neuroscience Division, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA;2. Departments of Psychiatry and Neurology, John Hopkins University, Baltimore, MD, USA;3. Departments of Psychology, Neurology and Neuroscience, and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA;4. Center for Cognitive Neuroscience, Department of Psychology and Neuroscience, Duke University, Durham, NC, USA;5. Department of Neurology, Harvard Medical School, Boston, MA, USA;6. Laboratory of Behavioral Neuroscience, Neurocognitive Aging Section, National Institute on Aging, Baltimore, MD, USA |
| Abstract: | The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of 3H]oxotremorine-M-acetate and oxotremorine/3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebral cortex whose mAchR were dominantly of M1 type. Somatostatin did not alter agonist binding in the medulla-pons where M2 receptors were abundant. Therefore, the effect of somatostatin on mAchR seems to be selective to high affinity binding sites of M1 receptors. |
| Keywords: | muscarinic acetylcholine receptor receptor subtype somatostatin rat brain receptor binding assay |
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