噻奈普汀与多虑平治疗老年抑郁症对照研究

目的：观察噻奈普汀治疗老年抑郁症的疗效和安全性。方法：随机将60例年龄≥60岁的老年抑郁症患者分为多虑平组（30例）和噻奈普汀组（30例），疗程6周，采用汉密尔顿抑郁量表（HAMD）和副反应量表（TESS）在治疗前和治疗后1、2、4、6周末评定药物疗效和不良反应。结果：两组疗效无显著差异，HAMD总分及各因子分从疗后2周至6周均较治疗前显著降低，两组间比较无显著性差异；治疗结束时TESS评分噻奈普汀组显著低于多虑平组。结论：噻奈普汀疗效好，不良反应少，适合于老年抑郁症特别是伴有躯体疾病患者的治疗，服用方便、安全，可首选使用。

A control study of Tianeptine and doxepine in the treatment of elderly depressive patients

Objective:To study the efficacy and safety of tianeptine in the treatment of depressive patients.Methods:60 depressed patients were randomized into tianeptine group(n=30) and doxepine(n=30) and studied for 6 weeks.HAMD and TESS were used to assess the efficacy and side effects before and 1week,2weeks,4weeks and 6weeks after the treatment.Results: There was no significant difference in efficacy between the two groups.HAMD scores and the factor scores from week2 to week 6 decreased dramatically as compared to pretreatment,no significant difference was observed between the two groups.After the trial the TESS scores in tianeptine group were significantly lower than that of doxepine group.Conclusions: tianeptine was an effective,convenient and safe treatment in elderly depressive patients and especially suit to the patients with somatic diseases.It had few side effects and can be a first drug choice.