| 米氏消除药物静脉给药的药动学方程数值解 |
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| 引用本文： | 林中,苏银法. 米氏消除药物静脉给药的药动学方程数值解[J]. 药学进展, 2004, 28(12): 565-567 |
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| 作者姓名： | 林中 苏银法 |
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| 作者单位： | 温州市第二人民医院临床药学科,浙江,温州,325000 |
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| 摘 要： | 的：获得(一级并行)米氏消除药物静脉注射给药时的血药浓度近似解。方法：根据四阶Runge-Kutt。算法，采用Excel软件编写基于药动学参数的程序。结果：输出某周期或稳态任一次给药后的预期血药浓度。结论：方法操作简单，结果可靠，可作为(一级并行)米氏消除药物静脉注射给药时药动学方程的数值解法。
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| 关 键 词： | 米氏消除 Runge-Kutta算法 静脉给药 药物动力学 Excel软件 |
| 文章编号： | 1001-5094(2004)12-0565-03 |
| 修稿时间： | 2004-06-14 |
A Numerical Method for Plasma Concentration of Drugs Obeying Michaelis-Menten Clearance Kinetics by Bolus Intravenous Administration |
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| LIN Zheng,SU Yin-fa. A Numerical Method for Plasma Concentration of Drugs Obeying Michaelis-Menten Clearance Kinetics by Bolus Intravenous Administration[J]. Progress in Pharmaceutical Sciences, 2004, 28(12): 565-567 |
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| Authors: | LIN Zheng SU Yin-fa |
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| Abstract: | Objective: To establish a numerical method for plasma concentration of drugs obeying parallel first order and Michaelis-Menten clearance kinetics by bolus intravenous administration. Methods: Microsoft Excel was used to write a Microsoft Excel spreadsheet based on the four stage Runge-Kutta algorithm. Results: After inputting the pharmacokinetic parameters(Vm, Km, Vd, k), the Microsoft Excel spreadsheet displayed plasma concentration at mini-interval after the administration. Conclusion: The four stage Runge-Kutta algorithm is a reliable numerical method for plasma concentration of drugs obeying parallel first order and Michaelis-Menten clearance kinetics by intravenous administration. |
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| Keywords: | Michaelis-Menten clearance Runge-Kutta algorithm Bolus intravenous administration Pharmacokinetics Excel software |
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