绿茶提取物EGCG抑制致龋菌变形链球菌生长、产酸的实验研究

目的 初步探讨绿茶提取物表没食子儿茶素没食子酸酯（EGCG）对变形链球菌生长、产酸的抑制作用,为龋病的防治提供一定的依据。方法 采用抑菌环实验观察EGCG对变形链球菌生长的影响,检测其对变形链球菌产酸能力的影响。结果 EGCG对变形链球菌生长、产酸有显著的抑制作用,最低抑菌浓度为6.25 mg/L,且随着药物浓度的增加,抑菌圈直径越大,pH值变化越小。结论 EGCG是一种潜在的天然抗菌、防龋药物。

Experimental Study on the Inhibition of the Growth and Reducing Acid Production of Streptococcus Mutans with Green Tea Extracts EGCG

Objective To investigate the effect of green tea extracts Epigallocatechin gallate（EGCG） on inhibiting the growth and reducing acid production of Streptococcus mutans, and to provide evidence for the prevention of den tal caries. Methods The inhibition zone was used to observe the effects of EGCG on growth of Streptococcus mutans and the changes of acid producing capacity of Streptococcus mutans. Results EGCG could inhibit the growth and reduce the acid production of Streptococcus mutans significantly. The minimum in- hibitory concentrations was 6.25 mg/L. With the increase of drug concentration, the diameter of the inhibition zone increased. But the changes of pH was reduced. Conclusion EGCG may be a potential antibacterial and anticaries medicine