氮酮对消炎止痒搽剂中黄芩苷透皮吸收的影响研究

目的研究消炎止痒搽剂中不同氮酮浓度对黄芩苷的离体透皮吸收特性，为该制剂的制备工艺提供依据。方法以离体sD大鼠腹部皮肤为渗透屏障，采用Franz垂直扩散池，以UPLC测定接受液中黄芩苷的含量，考察不同氮酮浓度对黄芩苷累积透皮吸收量的影响。结果与不含氮酮促进剂相比，氮酮可以促进黄芩苷的吸收，且浓度对黄芩苷的透皮吸收有影响，其中氮酮浓度2．5％时，黄芩苷的累积透皮吸收量最大，渗透率为0．4932Ixg·cm-2·h-1。结论氮酮可以促进}肖炎止痒搽剂中黄芩苷的透皮吸收，浓度为2．5％时效果较好。

Effect of Concentration of Azone on Percutaneous Absorption of Baicalin in Xiaoyan Zhiyang Linimentum

Objective To explore the percutaneous absorption characteristic of different concentration of azone on baicalin in Xiaoyan Zhiyang linimentum, so as to provide reference for its preparation technology. Methods The transdermal constants of baicalin via SD mouse＇ s skin were determined with Franz diffusion cell, and the contents of baicalin were assayed by ultra-high performance liquid chromatography （UPLC）. The absorption was estimated by the baicalin accumulation. Results The penetration rate increased with the existence of transdermal enhancer azone. When the concentration of azone at 2.5%, the penetration rate of baicalin is the highest, up to 0. 493 2 p.g ~ cm-2 . h-1. Conclusion The azone could enhance the penetration rate of baicalin, and the enhance effect is favorable when its concentration is at 2.5%.