高同型半胱氨酸血症与视神经脊髓炎关系的探讨

目的探讨视神经脊髓炎(NMO)患者体内同型半胱氨酸(Hcy)水平的变化。方法检测51例NMO患者(NMO组)和55名健康人群(对照组)的血清Hcy水平;比较具有不同水通道蛋白4抗体(AQP4-ab)状态以及NMO病灶数量与Hcy水平的关系。结果 NMO组和对照组血清Hcy浓度分别为(14.919±5.443)μmol·L-1和(10.426±3.256)μmol·L-1,差异有显著统计学意义(P0.01);男性NMO患者Hcy水平明显高于女性患者(P0.01)。AQP4-ab阳性和阴性的NMO患者Hcy分别为(15.121±5.694)μmol·L-1和(14.476±4.996)μmol·L-1,差异无统计学意义(P=0.699)。NMO多病灶和单病灶患者Hcy分别为(16.494±5.669)μmol·L-1和(13.902±5.129)μmol·L-1,多病灶患者Hcy平均水平高于单病灶患者,但差异无统计学意义(P=0.097)。两组维生素B12和叶酸水平比较,均差异无统计学意义(P0.05)。结论 NMO患者,尤其是男性患者具有较高的Hcy水平,与体内叶酸、维生素B12水平和AQP4-ab状态无关。

Increased Plasma Homocysteine Levels in Patients with Neuromyelitis Optica

Aim To assess the plasma levels ofhomocysteine （Hcy） in patients with neuromyelitis optica （NMO）.Methods Plasma Hcy,vitamin B12 and folate were measured in 35 aquoporin 4 antibody （AQP4-ab） positive and 16 negative NMO patients and 55 healthy controls.Results Hcy levels were significantly increased in NMO patients compared to the controls [（14.919 ± 5.443） μmol·L-1 vs （10.426 ± 3.256） μmol·L-1,P〈0.01].In comparison with female patients,male had higher levels of Hcy [（18.810 ± 5.867） μmol·L-1 vs （13.848 ±4.870） μmol·L-1,P〈0.01].Hcy levels were not fluctuated with sero-status ofAQP4-ab.A trend for higher Hcy levels was found in patients with multifocal lesions,even the association between Hcy levels and number of lesions was not confirmed in the statistical analysis.Plasma Hcy was not related to vitamin B12 and folate in NMO patients.Conclusion Plasma were significantly increased in NMO,especially in male patients.Further study is warranted in order to elucidate the pathological mechanisms and clinical implications of this finding.