Madopar HBS in fluctuating parkinsonian patients: two-year treatment |
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Authors: | G Pezzoli S Tesei C Ferrante E Cossutta A Zecchinelli G Scarlato |
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Institution: | Istituto di Clinica Neurologica, Università di Milano, Italy. |
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Abstract: | In an open-label study, we substituted conventional levodopa plus benserazide: 100/25 (Madopar) with a controlled-release form (HBS) in 18 fluctuating parkinsonian patients for 24 months. Significantly positive results were obtained in both peak-dose and diphasic dyskinesias up to 12 months of treatment; morning akinesias were also improved up to 6 months. A general trend of deterioration, compared to the first 3-6 months of HBS treatment, was observed in "off" fluctuations after 1 year: akinesias due to a delayed response worsened after 1 year of treatment also when compared with the conventional treatment. Positive results were obtained with new HBS on standard Madopar-related psychiatric disorders. |
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