老年系统性红斑狼疮合并冠心病患者的临床特征分析

目的：探讨老年系统性红斑狼疮（SLE）合并冠心病患者的临床特征。方法入选SLE合并冠心病的老年患者30例作为观察组，同期单纯冠心病老年患者30例作为对照组，对比两组患者的基本特征、生化指标、危险因素、心血管病变等。结果观察组男性患者10例、高脂血症病史者3例、吸烟史者3例和危险个数（1．2±1．2）例，均显著少于对照组19例、13例、15例、（2．6±1．3）例，差异均有统计学意义（ P＜0．05），女性患者显著多于对照组，体质量指数显著低于对照组，差异有统计学意义（P＜0．05）；两组患者血脂水平、尿素氮和血肌酐差异均无统计学意义（P＞0．05），但观察组肝功能指标明显高于对照组，差异有统计学意义（P＜0．05）；观察组主要以三支血管病变为主，单支血管病变者显著低于对照组，三支血管病变者显著高于对照组，差异有统计学意义（P＜0．05）。结论老年SLE 合并冠心病好发于女性，危险因素个数较少，肝功能差，冠状动脉病变严重。

Clinical characteristics of systemic lupus erythematosus complicated with coronary heart disease in elderly patients

Objective To analyze the clinical characteristics of systemic lupus erythematosus （SLE） complicat-ed with coronary heart disease （CHD） in elderly patients .Methods A total of 30 elderly patients combined with SLE and CHD were enrolled as observation group ,and 30 elderly patients with CHD were enrolled as control group .Basic characteristics ,biochemical indexes ,risk factors ,cardiovascular disease and so on were compared between the two groups .Results In observation group ,there were 10 cases of male patient ,3 cases with hyperlipidemia history ,3 ca-ses with smoking history and the dangerous number was （1 .2 ± 1 .2） cases ,which were significantly less than the 19 cases ,13 cases ,15 cases and （2 .6 ± 1 .3） cases of control group respectively （P〈0 .05） ,the proportion of female pa-tients was significantly higher than control group ,but body mass index was significantly lower than control group （P〈0 .05） .The differences of levels of blood lipid ,urea nitrogen and creatinine were not significant （P〉0 .05） ,but levels of liver function indexes in observation group was significantly higher than control group （P〈0 .05） .Propor-tion of patients with three lesions in observation group was significantly higher than control group （P〈0 .05） .Con-clusion Elderly SLE complicated with CHD might occur mainly in females ,with less numbers of risk factors ,poor liver function and severe pathological changes of coronary artery .