Localization of endogenous galactoside-binding lectin during morphogenesis ofXenopus laevis |
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Authors: | Nadine C Milos Yanling Ma Parag V Varma Michael P Bering Zarina Mohamed Linda M Pilarski and Yvette N Frunchak |
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Institution: | (1) Department of Oral Biology, University of Alberta, T6G 2N8 Edmonton, Alberta, Canada;(2) Department of Immunology, University of Alberta, T6G 2N8 Edmonton, Alberta, Canada |
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Abstract: | Summary A monoclonal antibody has been produced againstXenopus laevis galactoside-binding neural-creststage lectin. This antibody inhibits lectin-mediated hemagglutination. Using this antibody
in conjunction with immunohistochemical techniques, lectin deposition has been studied in embryos and tadpoles at different
stages of morphogenesis, from initial neural crest migration, up to the formation of a swimming tadpole. Lectin levels change
during development in different regions of the embryo and tadpole, decreasing in migratory cells, and increasing in sites
where cells become more adhesive to one another. The results suggest that galactoside-binding lectins may be an important
class of cellular adhesion molecules during these stages of development. |
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Keywords: | Xenopus laevis Lectin Galactoside Monoclonal antibody |
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