Chemotactic peptides but not macrophage colony stimulating factor effect the synthesis of inositol lipids in macrophages. |
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Authors: | S J Vallance C H MacPhee C P Downes A D Whetton |
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Affiliation: | Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK. |
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Abstract: | Normal bone marrow derived macrophages display a wide variety of biological responses to a number of distinct agonists, for example, Macrophage Colony Stimulating Factor (M-CSF) and chemotactic peptides (such as FMLP). FMLP stimulates reactive oxygen intermediate production in these cells, whilst M-CSF stimulates DNA synthesis. We have compared the effects of these two agents on the production of novel inositol lipids in macrophages. Evidence is presented that FMLP, but not M-CSF elevate the levels of a lipid putatively identified as phosphatidylinositol-3,4-bisphosphate. The implications of this observation on proposed role of novel inositol lipids in macrophage proliferation are discussed. |
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