| 口腔磷癌组织中入乳头瘤病毒DNA的原位杂交研究 |
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| 引用本文： | 布静秋,胡敏,吕雅莉,陈乐真. 口腔磷癌组织中入乳头瘤病毒DNA的原位杂交研究[J]. 解放军医学杂志, 2001, 26(3): 210-211 |
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| 作者姓名： | 布静秋 胡敏 吕雅莉 陈乐真 |
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| 作者单位： | 解放军总医院 |
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| 摘 要： | 应用以高辛标记的HPV6/11和HPV16/18核酸探针分别在50例口腔鳞状细胞癌（OSCC）组织上进行原位杂交，以检测OSCC组织中HPV DNA的特征。结果表明，HPV16/18 DNA阳性16例（32%），HPV16/18 DNA阳性信号散在分布于OSCC的癌细胞核中；而检测HPV6/11 DNA均为阴性。结果提示，原位杂交方法可用来检测OSCC组织 HPV DNA的存在并能准确组织定位；进一步支持高危型HPV16/18感染与OSCC的发生有关。
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| 关 键 词： | 口腔肿瘤 原位杂交 人乳头瘤病毒DNA 口腔鳞癌 |
| 修稿时间： | 2000-10-25 |
DETECTION OF HUMANPAPILLOMAVIRUS DNA OF ORAL SQUAMOUS CELL CARCINOMAS BY IN SITU HYBRIDIZATION |
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| Bu Jingqiu. DETECTION OF HUMANPAPILLOMAVIRUS DNA OF ORAL SQUAMOUS CELL CARCINOMAS BY IN SITU HYBRIDIZATION[J]. Medical Journal of Chinese People's Liberation Army, 2001, 26(3): 210-211 |
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| Authors: | Bu Jingqiu |
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| Abstract: | By using digoxin labelled human papillomavirus(HPV) 6/11 and HPV16/18 probes,and hybridization in situ technique, the HPV DNA sequence in 50 cases of oral SCC was detected. The results showed that among them ,16 cases(32%) were positive for HPV16/18 DNA, none of the cases of OSCC was positive for HPV6/11 DNA. It was suggested that HPV16/18 in oral SCC was confirmed to be closely related with the cause of OSCC. |
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| Keywords: | mouth neoplasms in situ hybridization papillomavirus human |
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