Effects of hypergravity on the morphological properties of the vestibular sensory epithelium. II. Life-long exposure of rats including embryogenesis |
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| Authors: | Wubbels R J van Marle J Sondag H N P M de Jong H A A |
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| Affiliation: | Vestibular Department, ENT, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. r.j.wubbels@amc.uva.nl |
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| Abstract: | Rats were exposed to a hypergravity (HG) level of 2.5 x g from conception until the age of 14 weeks. The vestibular epithelia of four of these animals and four control animals were immunohistochemically labeled for actin and tubulin. The apical cross-sectional area of epithelial cells of HG exposed rats appeared to be larger in all end organs. Area increase was 7.0% in the utricle (p<0.005) and 8.2% in the crista (p<0.001). Hair cells and supporting cells appeared to be intact. The cellular arrangement and the proportion of different cell types within the epithelia was normal. |
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| Keywords: | Gravity Vestibular system Hair cell Actin Tubulin |
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