莫西沙星不同给药方案治疗老年社区获得性肺炎的比较

目的：比较莫西沙星两种不同给药方案治疗老年社区获得性肺炎的临床作用。方法选择我院2010年10月～2011年12月收治的108例老年社区获得性肺炎患者并随机分为两组，对照组54例常规应用莫西沙星静脉滴注治疗，观察组54例采用莫西沙星序贯治疗，比较两组的临床疗效及药物经济学情况。结果观察组总有效率98.1%，对照组为94.4%，组间差异无统计学意义（P＞0.05）；观察组不良反应发生率为3.7%，对照组为7.4%，组间差异无统计学意义（P＞0.05）；观察组的成本-效果比为1834.9，明显低于对照组的3787.1，差异有统计学意义（P＜0.05）。结论莫西沙星两种不同给药方案治疗老年社区获得性肺炎均可获得满意的临床疗效，且安全性好，但序贯疗法成本-效果比低，是优选的治疗方案。

Comparative study on two different dosage regimens of Moxifloxacin in the treatment of community acquired pneumonia in elderly patients

Objective To compare the clinical conditions of two different dosage regimens of Moxifloxacin in the treatment of community acquired pneumonia in elderly patients. Methods From October 2010 to December 2011 in our hospital, 108 elderly patients with community acquired pneumonia were selected and randomly divided into two groups, the control group（54 cases）treated with Moxifloxacin by conventional treatment, the observation group（40 cases）treated with Moxifloxacin by sequential treatment, the clinical efficacy and pharmacoeconomic efficacy of two groups were compared. Results The total ef ective rate of observation group was 98.1%,and the control group was 94.4%, there was no significant dif erence between two groups（P〉0.05）;the incidence of adverse reactions was 3.7%,and the control group was 7.4%, there was no significant dif erence between two groups （P〉0.05）;the cost-ef ectiveness ratio observation group was 1834.9, significantly lower than 3787.1 of the control group. Conclusion Two different dosage regimens of Moxifloxacin in the treatment of community acquired pneumonia in elderly patients can obtained satisfactory effect and good safety, but sequential treatment has lower cost-effectiveness ratio, it is the first choice of treatment program.