Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum |
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| Authors: | van Rossen M E Hofland L J van den Tol M P van Koetsveld P M Jeekel J Marquet R L van Eijck C H |
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| Institution: | Laboratory for Experimental Surgery and Oncology, Erasmus University Rotterdam, Dr Molewaterplein 50, PO Box 1738, 3000 DR Rotterdam, The Netherlands. |
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| Abstract: | In this experimental study, the effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum was investigated. A reproducible in vitro assay was developed to study the adhesion of CC531 colon carcinoma cells to an autologous monolayer of rat mesothelial cells. Tumour cell adhesion to mesothelium pre-incubated with interleukin-1beta (IL-1beta) and epidermal growth factor (EGF) resulted in at least 60% more tumour cell adhesion at maximal stimulation (p
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