Recombinant and nonrecombinant factor XIII and its effect on bone ingrowth and strength of fixation |
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| Authors: | H Kienapfel R Swain A Hettel A Wilke M Koller P Griss |
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| Institution: | (1) Zentrum Operative Medizin II, Orthopädische Klinik and Poliklinik, Philipps Universität, Baldingerstraße, D-35033 Marburg, Germany;(2) Institut für Theoretische Chirurgie, ZOM I, Philipps Universität, Marburg, Germany |
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| Abstract: | Thirty cylindrical, commercially pure, titanium fiber, porous-coated Ti6Al4V implants were inserted pressfit into the proximal humeral portion of 30 sheep humeri to determine the systemic effect of recombinant factor XIII and placenta-derived factor XIII concentrate on bone ingrowth and strength of fixation. For both the recombinant factor XIII and the factor XIII concentrate group, the volume of bone ingrowth and the strength of fixation were higher than for the control specimens. However, the difference was only significant for the factor XIII concentrate group. |
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