多囊卵巢综合征患者胰岛素抵抗与脂代谢的关系

目的:探讨多囊卵巢综合征(PCOS)患者胰岛素抵抗(IR)、肥胖及血脂代谢的关系。方法:把PCOS病人分成IR组(15例),非IR组(25例),另设正常育龄妇女为对照组(20例)三组,检测空腹血甘油三脂(TG)、总胆固醇(TC)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、葡萄糖耐量试验(OGTT)、胰岛素(INS)释放试验,并计算体重指数(BMI)和腰臀比(WHR)。结果:(1)BMI、WHR三组间差别有显著意义(P<0.05,P0.05),后者三组间差别有显著意义(P<0.05)。结论:PCOS病人的IR与肥胖及脂代谢关系密切,使发生心血管疾病风险增加。

Relationship between Insulin Resistance and Lipid Metabolism in Women with Polycystic Ovary Syndrome

Objective:To investigate the relationship between insulin resistance (IR), obesity and blood lipid metabolism in women with polycystic ovary syndrome (PCOS). Methods :Forty women with PCOS were divided in 2 groups; IR and Non-IR, with 15 and 25 cases respective, 20 normal women were included in normal control group. All women were undergone tests of fast plasma triglyceride(TG) , total cholesterol (TC), ApoAl, ApoB, HDL-c,LDL-c and insulin releasing test; their body mass index(BMI) and waist / hip radio(WHR) were determined. Results: (1) The difference between the BMI and WHR among the 3 groups was significant (P<0.05,P<0. 01). (2) The levels of TG, TC and ApoB decreased in turn from IR group, Non-IR group to normal control group, this difference was significant (P<0. 01,P<0. 05,P< 0. 01). The difference of HDL-c among the three groups was significent (P<0. 05). Conclusion;IR of the women with PCOS is closely related with obesity and lipid metabolism. As a result, the risk of cardiovascular diseases may increase.