气管灌注贫铀染毒对大鼠免疫功能的影响

目的 研究气管灌注贫铀染毒对大鼠免疫功能的影响。方法 大鼠气管单次灌注不同剂量的贫铀粉尘后，每周称体重，定期测定外周血细胞参数，活杀后分别测定免疫器官重量系数、脾细胞抗体生成细胞数、胸腺淋巴细胞及其分类细胞数。结果 气管灌注贫铀染毒后早期，大鼠体重减少，白细胞增高，红细胞、血小板降低，所有变化不同程度地存在剂量依赖关系，且在1～2个月内恢复到正常水平。脾和胸腺细胞的免疫功能均观察到剂量依赖性的异常改变。结论 气管灌注贫铀染毒对大鼠免疫功能有损伤作用。

Effect of intratracheally instilled depleted uranium on immunological function of rats

Objective To study immunological effects of depleted uranium in rats. Methods Wistar rats were exposed to depleted uranium by single intratracheal instillation.Body weight and peripheral blood cells were measured weekly and immunological functions were evaluated by weight coefficient of immune organs,plague forming cells of spleenocytes,total and subpopulation counts of lymphocytes in thymus. Results Early after administration,body weight decreased and red blood cells as well as platelets reduced while white blood cells increased,which returned to normal within 1 or 2 months.Immunological functions of spleenocytes and thymocytes were affected dosedependently by depleted uranium. Conclusion Depleted uranium induces immunological dysfunction in rats.;