Multiple cytogenetic aberrations in squamous cell carcinomas of the head and neck |
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| Affiliation: | 1. Department of Clinical Dental Sciences, University of Liverpool, P.O. Box 147, LiverpoolUK;2. Regional Cytogenetic Unit, Royal Liverpool Hospital, LiverpoolUK;3. Department of Otorhirolaryngology, University of Liverpool, P.O. Box 147, LiverpoolU.K.;1. Service pharmacie clinique, hôpital universitaire Necker–Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France;2. Service pharmacie clinique, hôpital Jean-Verdier, hôpitaux universitaires de Paris-Seine-Saint-Denis, Bondy, France;3. Service radiologie, hôpital Jean-Verdier, hôpitaux universitaires de Paris-Seine-Saint-Denis, Bondy, France;1. Department of Haematology and Oncology, Kasugai Municipal Hospital, Kasugai, Japan;2. School of Medicine, Fujita Medical University, Toyoake, Japan;3. Hematology Department, The Catalan Institute of Oncology–The Josep Carreras Leukaemia Research Institute, Hospital Germans Trias i Pujol, Badalona, Spain;4. Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St Mary''s Hospital, The Catholic University of Korea, Seoul, South Korea;5. Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan;6. Shimane University Hospital, Innovative Cancer Center/Oncology-Hematology, Izumo, Japan;7. Division of Hematology and Bone Marrow Transplantation, N N Blokhin Russian Cancer Research Center, Moscow, Russia;8. Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea;9. Northern Institute for Cancer Care, Newcastle University, Newcastle-upon-Tyne, UK;10. Department of Onco-Hematology, Portuguese Institute of Oncology, Porto, Portugal;11. Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St Petersburg, Russia;12. Department of Haematology, Jagiellonian University, Kraków, Poland;13. Department of Hematology, Hospital Arnau de Vilanova, Valencia, Spain;14. Department of Hematology, Nizhniy Novgorod Region Clinical Hospital, Nizhniy Novgorod, Russia;15. N N Alexandrov Republican Scientific and Practical Centre of Oncology and Medical Radiology, Minsk, Belarus;p. Department of Internal Medicine, Universidad de la Frontera, Temuco, Chile;q. Department of Medicine, Charles University, General Hospital in Prague, Prague, Czech Republic;r. Toni Stephenson Lymphoma Center and Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA;s. Department of Hematology, Hospices Civils de Lyon, Lyon, France;t. Comprehensive Cancer Center Ulm, University Hospital of Ulm, Ulm, Germany;u. Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;v. Celltrion, Inc., Incheon, South Korea;1. Faculty of Social Work, University of Calgary, Canada;2. Department of Psychology, University of Calgary, Canada;1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture Veterinary Medicine, Nishi 2 Sen-11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan;2. Central Diagnostic Laboratory, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, 7062, Kampala, Uganda;3. Research Center for Tick and Tick-borne Diseases Control, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, 7062, Kampala, Uganda;4. Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, 22511, Albeheira, Egypt;5. Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, 35516, Egypt;1. Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA;2. Department of Neurology, Harvard Medical School, Boston, MA, USA;3. Department of Neurological Surgery, University of California San Francisco and Weill Institute for Neurosciences, 513 parnassus avenue, health science suite 814, San Francisco, CA 94143, USA;4. Department of Neurology, Mayo Clinic Cancer Center, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA |
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| Abstract: | Chromosomal abnormalities in short term cultures have been investigated in 10 squamous cell carcinomas of the head and neck. Of these tumours, three demonstrated clonal chromosomal abnormalities, two showed random abnormalities and 5 patients' tumours had normal karyotypes. The 5 patients with aberrant karyotypes were all from previously treated tumours, of these, 4 patients had received radiotherapy and 1 surgery. On analysis of the three clonal tumours, two were found to be polyclonal, each with five separate clones. 116 breakpoints were demonstrated from the clonal data of these tumours, and all of the chromosomes were involved, apart from number 18. In this study we found three or more breakpoints at sites 1p36, 9q32 and 11q23. 1 of the patients investigated showed a clonal abnormality involving a breakpoint at the 11q13 site, with a further 2 patients having breakpoints at 1p22-sites previously reported to have marked clustering of cytogenetic abnormalities in oral cancer patients. Only further studies will demonstrate whether the breakpoints found are of clinical significance. |
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