Selective cytotoxic activity of cyclosporins against tumor cells from patients with B cell chronic lymphocytic leukemia |
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| Affiliation: | 1. Division of Clinical Pharmacology, University Hospital, Uppsala University, S-751 85 Uppsala, Sweden;2. Department of Medicine, University Hospital, Uppsala University, S-751 85 Uppsala, Sweden;3. Department of Pathology, University Hospital, Uppsala University, S-751 85 Uppsala, Sweden;4. Department of Oncology, University Hospital, Uppsala University, S-751 85 Uppsala, Sweden;1. Department of General Biology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, km 380, 86057-970 Londrina, PR, Brazil;2. Center of Health Science, State University of Londrina, Londrina, PR, Brazil;3. Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University “Júlio de Mesquita Filho”, Rodovia Araraquara-Jaú, Km 1, 14801-902 Araraquara, SP, Brazil;1. Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, China;2. Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China;3. Epilepsy Center and Department of Neurosurgery, The First Affiliated Hospital, Jinan University, Guangzhou, China |
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| Abstract: | A fluorometric microculture cytotoxicity assay was employed for the study of cyclosporin A induced cytotoxicity in tumor samples from patients with B type chronic lymphocytic leukemia (B-CLL). Tumor cells from patients with B-CLL were found to be significantly more sensitive to the cytotoxic actions of cyclosporin A than normal blood mononuclear cells and tumor cells obtained from patients with different types of acute leukemia and solid tumors. The effect of cyclosporin A on B-CLL samples could be reproduced by a non-immunosuppressive cyclosporin A analogue. One B-CLL patient treated with cyclosporin A responded with a significant decrease in tumor mass and alleviation of anemia and B symptoms. The results show that cyclosporin A and its non-immunosuppressive analogues appear selectively toxic to B-CLL cells, an observation which may have clinical implications. |
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