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Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro |
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| Authors: | Zhang Chuan-hai Wang Yi-fei Liu Xin-jian Lu Jia-Hai Qian Chui-wen Wan Zhuo-yue Yan Xin-ge Zheng Huan-ying Zhang Mei-ying Xiong Sheng Li Jiu-xiang Qi Shu-yuan |
| Affiliation: | 1. Department of Chemistry and Biology, West Anhui University, Lu'an 237012, China 2. Biomedical Research & Development Center, Ji-nan University, Guangzhou 510630, China 3. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China 4. Center for Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China 5. South China Institute of Botany, Graduate School of the Chinese Academy of Sciences, Guangzhou 510650, China |
| Abstract: | Severe acute respiratory syndrome(SARS) is the first severe viral epidemic we encountered his century,which once spread in more than thirty countriesin2003.1 The etiological agent of SARS has beenc onfirmed to be a novel coronavirus,namely SARS coronavirus(SARS-CoV),2,3 and the first outbreak of SARS has been successfully controlled world wide,but the identification of SARS-CoV isolated from wildanimals,the emergence of some sporadic SARS cases laterafter that outbreak,all suggest that the recurrence of such an epidemic is not unlikely in the future.In this case,development of SARS vaccines and specific drugs is undoubtedlyessential to the control and prevention from the possible outbreak.4,5 |
| Keywords: | cepharanthine severe acute respiratory syndrome coronavirus antiviral activity |
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