外周血CD4^＋CD25^＋CD127^-调节性T细胞在过敏性紫癜中的表达及意义

目的 探讨外周血CD4^＋CD25^＋CD127^＋调节性T细胞在HSP患儿治疗前和治疗后的表达及其临床意义。方法选取HSP患儿4l例作为观察组，选取健康儿童41例作为对照组，检测对照组儿童及观察组患儿治疗前后的CD4^＋CD25^＋CD127^＋值。结果（1）治疗前与对照组比较，CD4^＋CD25^＋CD127^＋明显降低（P〈0．05）；（2）与治疗前比较，观察组患儿的CD4^＋CD25^＋CD127^＋值在治疗后明显升高（P〈0．05）；（3）与对照组比较，观察组患儿治疗后CD4^＋CD25^＋CD127^＋值差异无显著性（P〉0．05）。结论外周血CD4^＋CD25^＋CD127^＋值在HSP患儿治疗前显著降低，给予有效的治疗后其值显著升高，可能在HSP的发生发展过程中调节性T细胞进行了参与。而对于HSP患儿对疾病的有效预测．可以对其CD4^＋CD25^＋CD127^＋值进行测定。

Expression and significance of peripheral blood CD4+CD25+CD127-regulatory T cells of children with Henoch-Schonlein purpura

Objective To explore the level of CD4+CD25+CD127+regulatory T cells in children with Henoch-Schonlein purpura before and after treatment and its clinical significance.Methods Selected 41 cases with Henoch-Schonlein purpura as the observation group and 41 cases of healthy children as control group,test CD4+CD25+CD127+ in two group.Results(1)Before treatment compared with control group,CD4+CD25+CD127+ significantly lower(P<0.05);(2)Before treatment and observation groups,the observation group of children with CD4+CD25+CD127+ the value was significantly higher after treatment(P>0.05);(3)Compared with the control group,study group patients after treatment CD4+CD25+CD127+ value of the difference was not statistically significant(P>0.05).Conclusion Peripheral blood CD4+CD25+CD127+ value in the treatment of children with Henoch-Schonlein purpura were significantly reduced,giving an effective treatment significantly increased its value,may be allergic purpura development of the disease process of regulatory T cells were involved.For children with Henoch-Schonlein purpura predict the disease,can their CD4+CD25+ CD127+ values were determined.