| 多环胺化合物HH01抗实验性大鼠胃溃疡作用 |
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| 引用本文： | 张守仁,崔光建,徐瑞明,韩超,郭积玉. 多环胺化合物HH01抗实验性大鼠胃溃疡作用[J]. 药学学报, 1995, 30(2): 103-106 |
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| 作者姓名： | 张守仁 崔光建 徐瑞明 韩超 郭积玉 |
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| 作者单位： | 中国医学科学院、北京协和医科大学药物研究所 |
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| 摘 要： | HH01(A和B)在60mg·kg-1剂量下,对无水乙醇型、冷应激型和幽门结扎型胃溃疡模型有较好的预防作用;大剂量时对胃液分泌有一定的抑制作用,并可减少胃酸分泌,同时减少胃液中DNA的含量,作用特点与甲氰脒胍不同;在同样剂量下对消炎痛型胃溃疡模型无效。
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| 关 键 词： | 多环胺 1-甲基-3 10-六氢-7H-环戊烷并(j k)-1 3-二氧戊环[4 |
| 收稿时间： | 1994-08-29 |
ANTIULCER EFFECT OF POLYCYCLICAMINE COMPOUND HH01 ON EXPERIMENTAL GASTRIC ULCER IN RATS |
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| SR Zhang,GJ Cui,RM Xu,C Han and JY Guo. ANTIULCER EFFECT OF POLYCYCLICAMINE COMPOUND HH01 ON EXPERIMENTAL GASTRIC ULCER IN RATS[J]. Acta pharmaceutica Sinica, 1995, 30(2): 103-106 |
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| Authors: | SR Zhang GJ Cui RM Xu C Han JY Guo |
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| Abstract: | HH01(l-methyl-3,4,5,6,9, 10-hexahydro-7H-cyclopenta[j,k]-1,3-dioxolo[4,5-h]-pyrrolo[2,1-b][3]-benzazepine) A and B in doses 30 mg· kg-l and 60 mg, kg-l wereshown to protect gastric mucosa of rats from damage induced by absolute ethanol , cold-immersionstress and pylorus ligation. No effect was found in indomethacin model in mice. HH01 was found todecrease secretion of gastric juice and HCI in pylorus ligated rats. The content of DNA in gastric juiceof animals treated with HH01 was lower than in control. The results suggest that HH01 is effective asan anti-ulcer agent , but its mechanism of action is yet unknown. |
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| Keywords: | Polycyclicamine l-methyl-3 4 5 6 9 10-hexahydro-7H-cyclopenta[j k]-1 3-dioxolo[4 5-h]-pyrrolo[2 1-b][3]-benzazepine Experimental gastric ulcer |
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