脑血管病ACE基因缺失多态性的初步研究

目的 探讨血管紧张素转化酶（ＡＣＥ）基因缺失多态性与中国人脑梗死、高血压性脑出血的关系。方法 应用聚合酶链反应（ＰＣＲ）方法,检测５８例脑梗死患者、３１例高血压性脑出血患者以及６０名正常人的ＡＣＥ基因型。结果 高血压性脑出血组缺失纯合子（ＤＤ）基因型频率为２６％,与正常对照组比较有显著性差异（Ｐ〈０．０５）;脑梗死组ＤＤ基因型频经为２１％,与正常对照组比无显著性差异（Ｐ〉０．０５）,但进一步分析表

Preliminary study on ACE gene deletion polymorphism in patients with cerebrovascular disease

Objective To investigate the relationship between the angiotensin converting enzyme (ACE) gene deletion polymorphism and cerebral infarction,hypertensive cerebral hemorrhage in Chinese.Methods With polymerase chain reaction( PCR) method,we detec ted ACE genotypes in 58 patients with cerebral infarction,31 patients with hypertensive cerebral hemorrhage and 60 healthy controls.Results There was significant diffe rence between the frequencies of DD genotype in hypertensive hemorrhage (26%) and healthy controls(P<0.05).There was no significant difference between the frequency of DD genotype in cerebral infarction group (21%) and healthy controls(P>0.05),but the frequencies of DD genotype among cerebral infarction patients with hypertention(27%) and female cerebral infarction patients (26%) had more significant difference than those of healthy controls (P<0.05).Conclusion ACE gene deletion polymorphysm might be a susceptible factor of cerebral infarction and hemorrhage in Chinese patients with hypertension,and might be a risk factor for female patients with cerebral infarction.