损伤性窒息犬大脑皮质运动区单胺类递质的变化

目的 探讨损伤性窒息犬大脑皮质运动区单胺类递质的变化，为其治疗提供科学依据。方法 建立犬损伤性窒息脑损害模型，用高效液相电化学方法（ＨＰＬＣ－ＤＣ）测定大脑皮质中单胺类递质及其代谢产物在不同时间的改变。结果 大脑皮质运动区在损伤后２小时５－羟吲哚乙酸（５－ＨＩＡＡ）明显升高；８小时后５－羟色胺（５－ＨＴ）、高香草酸（ＨＶＡ）升高；去甲肾上腺素（ＮＥ）及３、４－双羟苯乙酸（ＤＯＰＡＣ）变化不明显。结论 单胺类神经递质参与了损伤性窒息后继发脑损害的病理过程，早期应用５－羟色胺拮抗剂或合成抑制剂是治疗损伤性窒息脑损害的一个可行方法。

Changes on monoamine neurotransmitter in cerebral cortex motor area of traumatic asphyxia canine

Objective To investigate the change on monoamine neurotransmitter in cerebral cortex motor area of traumatic asphyxia canines and provide scientific basis for its therapy.Methods The model of canine traumatic asphyxia was established,the change on monoamine neurotransmitter in cerebral cortex (motor area) and the products of metabolism during different time were tested with HPLC DC method.Results At 2 h after damage in cerebral cortex 5 hydroxyindolecetic acid (5 HIAA) elevated remarkably; At 8 h after da mage 5 hydroxytryptamine (5 HT), homovanillic acid (HVA) elevated; but there was no obvious change on norepinephrine(NE) and 3,4 dihydroxyphenyl acetic acid (DOPAC).Conclusion The monoamine neurotransmitters might play an important role in the pathological course of secondary brain injury after traumatic asphyxia.The utilization of 5 HT antagonists or compound inhibitor at early stage was a reliable method for treating brain injury after traumatic asphyxia.