| 骨桥蛋白与肺纤维化的研究进展 |
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| 引用本文： | 贺海彪,顾振纶,蒋小岗,周文轩,郭次仪. 骨桥蛋白与肺纤维化的研究进展[J]. 中国药理学通报, 2010, 26(2) |
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| 作者姓名： | 贺海彪 顾振纶 蒋小岗 周文轩 郭次仪 |
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| 作者单位： | 1. 苏州大学医学部药理学系,江苏,苏州,215007;苏州中药研究所,江苏,苏州,215007
2. 苏州中药研究所,江苏,苏州,215007;香港保健协会,中国,香港 |
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| 基金项目： | 江苏省中医药管理局资助项目,香港保健协会研究资助项目 |
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| 摘 要： | 骨桥蛋白(osteopontin,OPN)是一种分泌型糖基化磷蛋白,广泛存在于各种组织和体液中,具有多种生物学活性,整合素αvβ3是其主要受体。OPN主要参与细胞的增殖、分化、迁移及黏附。目前国内外对OPN的研究主要集中在骨吸收、血管生成、动脉粥样硬化、消化系统、泌尿系统、创面愈合、皮肤纤维化、肝纤维化、肾纤维化等方面,而在肺纤维化方面的研究报道较少,现将OPN与肺纤维化的关系作一综述。
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| 关 键 词： | 骨桥蛋白 肺纤维化 细胞外基质 成纤维细胞 肺泡上皮细胞 上皮间充质转变 信号通路 |
Research progress in osteopontin and pulmonary fibrosis |
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| HE Hai-biao,GU Zhen-lun,JIANG Xiao-gang,ZHOU Wen-xuan,Guo Ci-yi. Research progress in osteopontin and pulmonary fibrosis[J]. Chinese Pharmacological Bulletin, 2010, 26(2) |
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| Authors: | HE Hai-biao GU Zhen-lun JIANG Xiao-gang ZHOU Wen-xuan Guo Ci-yi |
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| Affiliation: | HE Hai-biao1,2,GU Zhen-lun1,JIANG Xiao-gang1,ZHOU Wen-xuan2,3,Guo Ci-yi2,3 (1.Dept of Pharmacology,Soochow University,Suzhou Jiangsu 215007,China,2.Suzhou Institute of Chinese Materia Medica,3.The Hong Kong Association for Health Care LTD,Hong Kong,China) |
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| Abstract: | Osteopontin (OPN) is a secreted O-glycosylated phosphoprotein that exists in a variety of tissues and body fluids, with a variety of biological activity. Integrin α_vβ_3 is the main receptor. OPN mainly involves in cell proliferation, differentiation, migration and adhesion. The study of OPN at home and abroad mainly focuses on the bone resorption, angiogenesis, atherosclerosis, digestive system, urinary system, wound healing, skin fibrosis, liver fibrosis, kidney fibrosis, etc.But reports about OPN in pulmonary fibrosis are much less, now the relationships between OPN and pulmonary fibrosis are reviewed. |
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| Keywords: | osteopontin pulmonary fibrosis extracellular matrix fibroblast alveolar epithelial cell epithelial-mesenchymal-transition signal transduction |
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