The effect of methamphetamine on the norepinephrine and 5-hydroxytryptamine contents in eleven rat brain regions

The effect of methamphetamine (MA) on the norepinephrine (NE) and 5-hydroxytryptamine (5-HT) contents in 11 rat brain regions has been investigated. MA, when administered in a dosage of 5 mg/kg, affected the NE content of the different brain regions in 3 ways: (1) there was a decrease in the content in the olfactory bulb, thalamus and hypothalamus; (2) there were no statistically significant changes in the cerebral cortex, hippocampus, cerebellum, pons, medulla oblongata and striatum; and (3) there was an increase in the content within the tegmentum.