| 鸭跖草中α-糖苷酶抑制活性多羟基生物碱类成分的ESIMS检识 |
| |
| 引用本文： | 王国平,邓美勇,周光雄,黄美燕,叶文才,叶春玲. 鸭跖草中α-糖苷酶抑制活性多羟基生物碱类成分的ESIMS检识[J]. 中药材, 2007, 30(2): 157-160 |
| |
| 作者姓名： | 王国平 邓美勇 周光雄 黄美燕 叶文才 叶春玲 |
| |
| 作者单位： | 1. 安徽省休宁县中医院,安徽黄山,245400
2. 暨南大学药学院,广东广州,510632 |
| |
| 基金项目： | 致谢：安徽皖南大鹏天然产物有限公司帮助进行水提取物的提取. |
| |
| 摘 要： | 为了检识国产鸭跖草(Commelina communis L.)药材中多羟基生物碱类α-糖苷酶抑制剂成分,采用水提取、醇沉淀,再经离子交换树脂和葡聚糖LH20层析等步骤从鸭跖草中提取、富集和纯化总碱部位;采用离子阱电喷雾离子化质谱(ESIMS)检测总生物碱中多羟基生物碱成分。从安徽绩溪产鸭跖草药材中检识到文献报道的多羟基生物碱成分,并可能提示存在文献未报道的其他多羟基生物碱类成分。研究结果表明国产鸭跖草药材含有多羟基生物碱类α-糖苷酶抑制剂,可用于糖尿病治疗和保健使用。
|
| 关 键 词： | 鸭跖草 多羟基生物碱 电喷雾离子化质谱 |
| 文章编号： | 1001-4454(2007)02-0157-04 |
| 修稿时间： | 2006-09-11 |
Detection for α-glucosidase-inhibiting Polyhydroxyalkaloid Ingredients of Commelina communis L.by ESIMS |
| |
| WANG Guo-ping,DENG Mei-yong,ZHOU Guang-xiong,HUANG Mei-yan,YE Wen-cai,YE Chun-ling. Detection for α-glucosidase-inhibiting Polyhydroxyalkaloid Ingredients of Commelina communis L.by ESIMS[J]. Journal of Chinese medicinal materials, 2007, 30(2): 157-160 |
| |
| Authors: | WANG Guo-ping DENG Mei-yong ZHOU Guang-xiong HUANG Mei-yan YE Wen-cai YE Chun-ling |
| |
| Affiliation: | 1. Xiu-ning County TCM Hospital of Anhui Province, Huangshan 245400, China; 2. College of Pharmacy, Jinan University, Guangzhou 510632, China |
| |
| Abstract: | For detecting polyhydroxyalkaloids-type alpha-glucosidase-inhibiting ingredients of Commelina communis L grown in China, total alkaloids were obtained from the plant by extraction with water, removal of precipitation after the addition of alcohol, enrichment and purification by ion exchange resin and sephadex LH 20 chromatography. Polyhydroxyalkaloids in the total alkaloids were detected by ion trap electron-spray ionization mass spectra (ESIMS). Several reported and unreported polyhydroxyalkaloids in the plant were detected from the material collected from Jixi county, Anhui province. The crude drug growing in China contains alpha-glucosidase-inhibiting polyhydroxyalkaloids and can be used to therapy in diabetes. |
| |
| Keywords: | Commelina communis Polyhydroxyalkaloids Electron spray ionization mass spectra(ESIMS) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
