Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies |
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| Authors: | Peng Liu Caifang Gao Hongguo Chen Chi Teng Vong Xu Wu Xudong Tang Shengpeng Wang Yitao Wang |
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| Affiliation: | 1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China;2. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China;3. Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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| Abstract: | Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated. Drug delivery systems have been extensively studied to transmit therapeutics to inflamed colon sites through the enhanced permeability and retention (EPR) effect caused by the inflammation. However, the drug still could not achieve effective concentration value that merely utilized on EPR effect and display better therapeutic efficacy in the inflamed region because of nontargeted drug release. Substantial researches have shown that some specific receptors and cell adhesion molecules highly expresses on the surface of colonic endothelial and/or immune cells when IBD occurs, ligand-modified drug delivery systems targeting such receptors and cell adhesion molecules can specifically deliver drug into inflamed sites and obtain great curative effects. This review introduces the overexpressed receptors and cell adhesion molecules in inflamed colon sites and retrospects the drug delivery systems functionalized by related ligands. Finally, challenges and future directions in this field are presented to advance the development of the receptor-mediated targeted drug delivery systems for the therapy of IBD. |
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| Keywords: | Receptor-mediated target Inflammatory bowel disease Crohn's disease Ulcerative colitis Drug delivery Cell adhesion molecule Active target Targeted therapy ACQ" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" aggregation-caused quenching ADR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" adverse drug reaction AIE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" aggregation-induced emission BSA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" bovine serum albumin CAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" cell adhesion molecule CD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" Crohn's disease CRD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" cysteine-rich domain CS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" chondroitin sulfate CT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" computed tomography CTLD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" c-type lectin-like domain DCs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" dendritic cells DSS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" dextran sulfate sodium salt EGF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0175" }," $$" :[{" #name" :" text" ," _" :" epidermal growth factor EPR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0185" }," $$" :[{" #name" :" text" ," _" :" enhanced permeability and retention FNII" },{" #name" :" keyword" ," $" :{" id" :" kwrd0195" }," $$" :[{" #name" :" text" ," _" :" fibronectin type II domain FR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0205" }," $$" :[{" #name" :" text" ," _" :" folate receptor FRET" },{" #name" :" keyword" ," $" :{" id" :" kwrd0215" }," $$" :[{" #name" :" text" ," _" :" fluorescence resonance energy transfer GIT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0225" }," $$" :[{" #name" :" text" ," _" :" gastrointestinal tract HA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0235" }," $$" :[{" #name" :" text" ," _" :" hyaluronic acid HUVEC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0245" }," $$" :[{" #name" :" text" ," _" :" human umbilical vein endothelial cells IBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0255" }," $$" :[{" #name" :" text" ," _" :" inflammatory bowel disease ICAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0265" }," $$" :[{" #name" :" text" ," _" :" intercellular adhesion molecule LMWC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0275" }," $$" :[{" #name" :" text" ," _" :" low molecular weight chitosan LPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0285" }," $$" :[{" #name" :" text" ," _" :" lipopolysaccharide MAP4K4" },{" #name" :" keyword" ," $" :{" id" :" kwrd0295" }," $$" :[{" #name" :" text" ," _" :" mitogen-activated protein kinase kinase kinase kinase 4 MGL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0305" }," $$" :[{" #name" :" text" ," _" :" macrophage galactose lectin MPO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0315" }," $$" :[{" #name" :" text" ," _" :" myeloperoxidase MR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0325" }," $$" :[{" #name" :" text" ," _" :" mannose receptor MRI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0335" }," $$" :[{" #name" :" text" ," _" :" magnetic resonance imaging MPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0345" }," $$" :[{" #name" :" text" ," _" :" mononuclear phagocyte system PAMAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0355" }," $$" :[{" #name" :" text" ," _" :" poly(amidoamine) PepT1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0365" }," $$" :[{" #name" :" text" ," _" :" peptide transporter 1 PEI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0375" }," $$" :[{" #name" :" text" ," _" :" polyethylenimine PSGL-1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0385" }," $$" :[{" #name" :" text" ," _" :" P-selectin glycoprotein ligand-1 QDs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0395" }," $$" :[{" #name" :" text" ," _" :" quantum dots RES" },{" #name" :" keyword" ," $" :{" id" :" kwrd0405" }," $$" :[{" #name" :" text" ," _" :" reticuloendothelial system TfR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0415" }," $$" :[{" #name" :" text" ," _" :" transferrin receptor UC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0425" }," $$" :[{" #name" :" text" ," _" :" ulcerative colitis VCAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0435" }," $$" :[{" #name" :" text" ," _" :" vascular cell adhesion molecule |
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