Microneedle-based devices for point-of-care infectious disease diagnostics |
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| Authors: | Rachael V. Dixon Eldhose Skaria Wing Man Lau Philip Manning Mark A. Birch-Machin S. Moein Moghimi Keng Wooi Ng |
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| Affiliation: | 1. School of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK;2. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK;3. Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK |
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| Abstract: | Recent infectious disease outbreaks, such as COVID-19 and Ebola, have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb transmission. Successful diagnostic strategies critically depend on the efficiency of biological sampling and timely analysis. However, current diagnostic techniques are invasive/intrusive and present a severe bottleneck by requiring specialist equipment and trained personnel. Moreover, centralised test facilities are poorly accessible and the requirement to travel may increase disease transmission. Self-administrable, point-of-care (PoC) microneedle diagnostic devices could provide a viable solution to these problems. These miniature needle arrays can detect biomarkers in/from the skin in a minimally invasive manner to provide (near-) real-time diagnosis. Few microneedle devices have been developed specifically for infectious disease diagnosis, though similar technologies are well established in other fields and generally adaptable for infectious disease diagnosis. These include microneedles for biofluid extraction, microneedle sensors and analyte-capturing microneedles, or combinations thereof. Analyte sampling/detection from both blood and dermal interstitial fluid is possible. These technologies are in their early stages of development for infectious disease diagnostics, and there is a vast scope for further development. In this review, we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis. |
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| Keywords: | Microneedle Infectious disease Point-of-care diagnostics (PoC) Biomarker detection Skin Biosensor COVID-19 AC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" alternating current APCs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" antigen-presenting cells ASSURED" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable to end-users cfDNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" cell-free deoxyribonucleic acid CMOS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" complementary metal-oxide semiconductor COVID" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" coronavirus disease CSF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" cerebrospinal fluid CT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" computerised tomography CV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" cyclic voltammetry DC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" direct current DNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" deoxyribonucleic acid DPV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" differential pulse voltammetry EBV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" Epstein–Barr virus EDC/NHS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" 1-ethyl-3-(3-dimethylaminoproply) carbodiimide/" },{" #name" :" italic" ," _" :" N" },{" #name" :" __text__" ," _" :" -hydroxysuccinimide ELISA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" enzyme-linked immunosorbent assay GOx" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" glucose oxidase HIV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" human immunodeficiency virus HPLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" high performance liquid chromatography HRP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0230" }," $$" :[{" #name" :" text" ," _" :" horseradish peroxidase IgG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0240" }," $$" :[{" #name" :" text" ," _" :" immunoglobulin G IP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0250" }," $$" :[{" #name" :" text" ," _" :" iontophoresis ISF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0260" }," $$" :[{" #name" :" text" ," _" :" interstitial fluid JEV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0270" }," $$" :[{" #name" :" text" ," _" :" Japanese encephalitis virus MN" },{" #name" :" keyword" ," $" :{" id" :" kwrd0280" }," $$" :[{" #name" :" text" ," _" :" microneedle NA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0290" }," $$" :[{" #name" :" text" ," _" :" nucleic acid OBMT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0300" }," $$" :[{" #name" :" text" ," _" :" one-touch-activated blood multidiagnostic tool OPD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0310" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" italic" ," _" :" o" },{" #name" :" __text__" ," _" :" -phenylenediamine PCB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0320" }," $$" :[{" #name" :" text" ," _" :" printed circuit board PCR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0330" }," $$" :[{" #name" :" text" ," _" :" polymerase chain reaction PDMS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0340" }," $$" :[{" #name" :" text" ," _" :" polydimethylsiloxane PEDOT" },{" #name" :" 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scanning electron microscope SERS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0430" }," $$" :[{" #name" :" text" ," _" :" surface-enhanced Raman spectroscopy SWV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0440" }," $$" :[{" #name" :" text" ," _" :" square wave voltammetry TB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0450" }," $$" :[{" #name" :" text" ," _" :" tuberculosis UV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0460" }," $$" :[{" #name" :" text" ," _" :" ultraviolet VEGF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0470" }," $$" :[{" #name" :" text" ," _" :" vascular endothelial growth factor WHO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0480" }," $$" :[{" #name" :" text" ," _" :" World Health Organisation |
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