Mechanism of Resistance to an Antitubercular 2-Thiopyridine Derivative That Is Also Active against Burkholderia cenocepacia |
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| Authors: | Viola C Scoffone Francesca Spadaro Claudia Udine Vadim Makarov Marco Fondi Renato Fani Edda De Rossi Giovanna Riccardi Silvia Buroni |
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| Institution: | aDipartimento di Biologia e Biotecnologie L. Spallanzani, Università degli Studi di Pavia, Pavia, Italy;bRussian Academy of Sciences, A. N. Bach Institute of Biochemistry, Moscow, Russia;cDepartment of Biology, University of Florence, Sesto Fiorentino, Florence, Italy |
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| Abstract: | The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance. |
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