Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy |
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| Authors: | Shenwu Zhang Yuequan Wang Zhiqiang Kong Xuanbo Zhang Bingjun Sun Han Yu Qin Chen Cong Luo Jin Sun Zhonggui He |
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| Affiliation: | 1. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China |
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| Abstract: | Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG2K) is utilized to achieve core-matched PEGylating modification via the π‒π stacking effect and hydrophobic interaction between the PPa core and the PPa-PEG2K shell. Compared to PCL-PEG2K with similar molecular weight, PPa-PEG2K significantly increases the stability, prolongs the systemic circulation and improves the tumor-homing ability and ROS generation efficiency of PPa-nanoassembly. As a result, PPa/PPa-PEG2K NPs exert potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. Together, such a core-matched nanoassembly of pure photosensitizer provides a new strategy for the development of imaging-guided theragnostic nanomedicines. |
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| Keywords: | Pure drug-assembled nanomedicines Pure photosensitizer Pyropheophorbide a Core-matched Self-assembly Nanoassembly Imaging-guided Photodynamic therapy ACQ},{#name:keyword,$:{id:kwrd0055},$$:[{#name:text,_:aggregation caused quenching ALT},{#name:keyword,$:{id:kwrd0065},$$:[{#name:text,_:alanine aminotransferase AST},{#name:keyword,$:{id:kwrd0075},$$:[{#name:text,_:aspartate aminotransferase BUN},{#name:keyword,$:{id:kwrd0085},$$:[{#name:text,_:blood urine nitrogen CRE},{#name:keyword,$:{id:kwrd0095},$$:[{#name:text,_:creatinine DCFH-DA},{#name:keyword,$:{id:kwrd0105},$$:[{#name:text,_:2′,7′-dichlorofluorescein diacetate DDS},{#name:keyword,$:{id:kwrd0115},$$:[{#name:text,_:drug delivery system FBS},{#name:keyword,$:{id:kwrd0125},$$:[{#name:text,_:fetal bovine serum NaCl},{#name:keyword,$:{id:kwrd0135},$$:[{#name:text,_:sodium chloride nano-DDS},{#name:keyword,$:{id:kwrd0145},$$:[{#name:text,_:nanoparticulate drug delivery systems NPs},{#name:keyword,$:{id:kwrd0155},$$:[{#name:text,_:nanoparticles PBS},{#name:keyword,$:{id:kwrd0165},$$:[{#name:text,_:phosphate buffer solution PDANs},{#name:keyword,$:{id:kwrd0175},$$:[{#name:text,_:pure drug-assembled nanomedicines PDT},{#name:keyword,$:{id:kwrd0185},$$:[{#name:text,_:photodynamic therapy PPa},{#name:keyword,$:{id:kwrd0195},$$:[{#name:text,_:pyropheophorbide a PS},{#name:keyword,$:{id:kwrd0205},$$:[{#name:text,_:photosensitizer ROS},{#name:keyword,$:{id:kwrd0215},$$:[{#name:text,_:reactive oxygen species SDS},{#name:keyword,$:{id:kwrd0225},$$:[{#name:text,_:sodium dodecyl sulfate SOSG},{#name:keyword,$:{id:kwrd0235},$$:[{#name:text,_:Singlet Oxygen Sensor Green Reagent |
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