不同剂量阿托伐他汀钙治疗老年不稳定型心绞痛并高脂血症患者的治疗效果分析

目的不同剂量阿托伐他汀钙治疗老年不稳定型心绞痛并高脂血症患者治疗效果。方法96例不稳定型心绞痛并高脂血症患者,根据随机分组法分为对照组和实验组,每组48例。对照组给予10 mg/d阿托伐他汀钙进行治疗,实验组患者给予20 mg/d阿托伐他汀钙进行治疗。比较两组患者治疗前后心功能指标水平和治疗效果。结果治疗前,两组患者左心室射血分数、左心室舒张末期内径以及超氧化物歧化酶水平比较差异无统计学意义(P>0.05);治疗后,两组患者左心室射血分数、左心室舒张末期内径以及超氧化物歧化酶水平均较本组治疗前改善,且实验组改善程度优于对照组,差异具有统计学意义(P<0.05)。实验组患者治疗总有效率为97.92%,明显高于对照组的85.42%,差异具有统计学意义(P<0.05)。结论与10 mg/d阿托伐他汀钙相比,在治疗不稳定型心绞痛并高脂血症时,给予患者20 mg/d阿托伐他汀钙的治疗效果更显著,治疗后左心室射血分数、左心室舒张末期内径以及超氧化物歧化酶的改善幅度更明显,药效更佳,值得临床推广。

Analysis of therapeutic effect of different doses of atorvastatin calcium on elderly patients with unstable angina pectoris and hyperlipidemia

Objective To discuss the therapeutic effect of different doses of atorvastatin calcium on elderly patients with unstable angina pectoris and hyperlipidemia.Methods A total of 96 elderly patients with unstable angina pectoris and hyperlipidemia were randomly divided into control group and experimental group,with 48 cases in each group.The control group was treated by atorvastatin calcium 10 mg/d,and the experimental group was treated by atorvastatin calcium 20 mg/d.The level of cardiac function before and after treatment and therapeutic effect were compared between the two groups.Results Before treatment,there was no statistically significant difference in left ventricular ejection fraction,end diastolic diameter and superoxide dismutase level between the two groups(P>0.05).After treatment,the levels of left ventricular ejection fraction,end diastolic diameter and superoxide dismutase in the two groups was better than those before treatment,and the improvement of the experimental group was better than that of the control group.Their difference was statistically significant(P<0.05).The total effective rate of treatment was 97.92%in the experimental group was obviously higher than 85.42%in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with atorvastatin calcium 10 mg/d,the effect of atorvastatin calcium 20 mg/d is more significant in the treatment of unstable angina pectoris and hyperlipidemia.After treatment,the improvement of left ventricular ejection fraction,left ventricular end diastolic diameter and superoxide dismutase is more obvious,and the efficacy is better.It is worthy of clinical promotion.